Sibofix 200 Tablet (Rifaximin 200mg)

INTRODUCTION

SIBOFIX 200MG contains Rifaximin which belongs to the group of medicines called antibiotics. It is used to treat traveler´s diarrhea in adults when the diarrhea is not accompanied by any fever or blood in the stools, or when passed loose stools for 8 or more times in the past 24 hours. Travelers’ diarrhea is a common travel-related illness of digestive tract that commonly caused by eating contaminated food or drinking contaminated water during travel resulting in loose stools and abdominal cramps.

Rifaximin acts by inhibiting the synthesis of RNA in the susceptible bacteria, which stops bacterial transcription and arrests its growth. Along with this treatment, drink lots of fluids, such as water, squash or juice, to avoid dehydration. The duration of the treatment should not exceed more than 3 days. If you do not feel better or if you feel worse within or after 3 days of treatment, please inform your doctor. Your doctor might alter the dose or change the treatment.

The most common side effects of taking this medicine are headache, abdominal pain or bloating, constipation, diarrhea, nausea or vomiting. Taking this medicine, may also cause a reddish discolouration of your urine. If these symptoms bother you, contact your doctor. This medicine is not recommended for the treatment of diarrhea accompanied with fever, or blood in stools. Patients with severe stomach pain or with other GI disorders, should inform your doctor before taking this medicine. SIBOFIX 200MG is not recommended for use in pregnant, breastfeeding women and in children (aged below 18 years).

USES OF SIBOFIX 200MG

Treat traveler´s diarrhea in adults

HOW SIBOFIX 200MG WORKS

Rifaximin binds to beta-subunit of the enzyme called bacterial DNA-dependent RNA polymerase and inhibits the synthesis of RNA in susceptible bacteria. This binding stops bacterial transcription and translocation and arrests its growth.

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DIRECTIONS FOR USE

Take this medicine as directed by your physician. It can be taken with or without food. Swallow the medicine as whole with a glass of water. Do not crush or chew the medicine. The duration of the treatment should not exceed more than 3 days. If your symptoms persist for more than 3 days of treatment, please consult a doctor.

SIDE EFFECTS OF SIBOFIX 200MG

SERIOUS
Allergic reaction (such as rash, itching, shortness of breath, abnormal heartbeat, swelling of mouth, face, ankles or any other part of body, extreme tiredness, dizziness or feeling faint
COMMON
Headache
Wind or bloating
Abdominal pain
Constipation
Diarrhea
Nausea or vomiting
Painful or ineffective straining
Fever

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.

Bloating or wind:

Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptoms get worse, contact your doctor straight away.

Constipation:

Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

Headache:

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

WARNING & PRECAUTIONS

PREGNANCY
SIBOFIX 200MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING
SIBOFIX 200MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES
Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL
Avoid consumption of alcohol while taking this medicine.

ALLERGY
Do not take this medicine if you are allergic to rifaximin or to similar types of antibiotics (such as rifampicin or rifabutin).

OTHERS

Do not take this medicine, if you:

Have fever, blood in your stools, GI disorders (such as constipation, abdominal pain and vomiting) caused by blockage of bowel or if you passed 8 or more unformed stools in the last 24 hours

INTERACTIONS

Talk to your doctor, if you are taking,

Ciclosporin (used to suppress the body’s immune system)
Warfarin (used to prevent blood clotting)
Oral contraceptives (medicines used to prevent pregnancy)
Activated charcoal (used to treat wind or diarrhea)