Syncapone 50 Tablet (Levodopa 50mg / Carbidopa 12.5mg / Entacapone(200mg)

About Syncapone 50 Tablet 10’s

Syncapone 50 Tablet 10’s belongs to a class of drugs called ‘antiparkinson agents‘ a precursor of dopamine (chemical messenger in the brain) primarily used in the treatment of Parkinson’s disease with its symptoms including tremors, spasm, muscle stiffness and poor muscle control. Parkinson’s disease is a disorder of the central nervous system that affects movement and locomotion, which causes stiffness, shaking, difficulty in walking, coordination and balance. In Parkinson’s patients, there are low dopamine levels as the nerve cells of the brain (neurons) that produce dopamine begin to die.

Syncapone 50 Tablet 10’s contains Carbidopa, Levodopa, and Entacapone. Levodopa belongs to the central nervous system agents, while Carbidopa is a decarboxylase inhibitor. The medicinal component Levodopa changes into dopamine in the brain and helps to control movement. Carbidopa acts by preventing the breakdown of Levodopa in the bloodstream so that more Levodopa can reach to brain. On the other hand, Entacapone belongs to a class of COMT (catechol-o-methyltransferase enzyme) inhibitors which causes higher and more sustained levels of levodopa in blood, so that more Levodopa can reach the brain, leading to greater relief from the symptoms of Parkinson’s disease.

Take Syncapone 50 Tablet 10’s as prescribed by your doctor. You are suggested to take $ame as long as your doctor has prescribed it after checking your medical condition. The most common side effects of Syncapone 50 Tablet 10’s are nausea, vomiting, loss of appetite, light-headedness, lowered blood pressure, confusion, and dyskinesia (uncontrolled/involuntary muscle movement). Most of these side effects of Syncapone 50 Tablet 10’s do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Syncapone 50 Tablet 10’s or any other medicines, please tell your doctor. Do not take Syncapone 50 Tablet 10’s if you are pregnant or breastfeeding unless prescribed by the doctor. Syncapone 50 Tablet 10’s should not be given to children as safety and effectiveness have not been established. Syncapone 50 Tablet 10’s may cause hallucination (seeing or hearing things that are not there) in some cases if taken for a prolonged time. So, if you experience hallucinations while taking Syncapone 50 Tablet 10’s, please talk to your doctor immediately. Keep your doctor informed about your medicines and health condition and rule out any side-effects.

Uses of Syncapone 50 Tablet 10’s

Parkinson’s disease

Medicinal Benefits

Syncapone 50 Tablet 10’s is an antiparkinson agent that is used in the treatment of Parkinson’s disease. Syncapone 50 Tablet 10’s is a combination of three medicines, namely; Carbidopa, Levodopa, and Entacapone. Levodopa belongs to the class of medications name as central nervous system agents, While Carbidopa falls in decarboxylase inhibitors. The medicinal component Levodopa changes into dopamine in the brain and helps to control movement. At the same time, Carbidopa acts by preventing the breakdown of Levodopa in the bloodstream so that more Levodopa can effectively reach the brain to block acetylcholine (chemical messenger in the brain). Entacapone blocks a certain natural substance catechol-o-methyltransferase (COMT) (an enzyme that breaks down the levodopa in the body) which causes higher and more sustained levels of levodopa in blood, so that more Levodopa can reach the brain, leading to greater relief from the symptoms of Parkinson’s disease. This effect allows the levodopa to last longer in the body so that it doesn’t wear off before the next dose.

Related Product

Directions for Use

Syncapone 50 Tablet 10’s can be taken with or without food. It is better to take 30-60 minutes before eating a meal that allows for quick absorption from the intestine before food can interfere. It is suggested to take a light meal and avoid high protein foods. Take this medication separately by as many hours as required from any iron supplements or products that are rich in iron. Intake of iron can reduce the absorption of the medication. The tablet form of Syncapone 50 Tablet 10’s should be swallowed as a whole with an ample amount of water, do not chew or break the tablet.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Syncapone 50 Tablet 10’s

• Nausea
• Muscle pain
• Diarrhoea
• Lightheadedness
• Dizziness
• Stomach upset
• Blurred vision
• Anaemia
• Hypotension (low blood pressure)
• Dyskinesias (uncontrolled movement)
• Urine discolouration

In-Depth Precautions and Warning

Drug Warnings

Do not stop taking Syncapone 50 Tablet 10’s suddenly without talking to your doctor. It may result in a serious neuroleptic malignant syndrome (NMS) that causes fever, muscle cramps or stiffness, unusual body movements, fast heartbeat, sweating, change in thinking, and confusion. Do not take Syncapone 50 Tablet 10’s if you are allergic to Syncapone 50 Tablet 10’s or any of its ingredients. Tell your doctor, if you have any medical history of diabetes, heart attacks, mental illness, stomach ulcers, heart disease, or recently gone through a surgical procedure. Syncapone 50 Tablet 10’s may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, especially when you start taking Syncapone 50 Tablet 10’s so please get up gradually. Besides this, a prolonged intake of Syncapone 50 Tablet 10’s may lead to greater neuropathy chances (nerve damage). Syncapone 50 Tablet 10’s should be given with caution in patients with eye problems (narrow-angle glaucoma), irregular heartbeat (arrhythmia), gastrointestinal bleeding, and psychosis. The use of Syncapone 50 Tablet 10’s is restricted if a person takes monoamine oxidase inhibitors (MAOs) or antidepressant drugs like isocarboxazid, phenelzine, selegiline, and tranylcypromine because it can lead to high blood pressure (hypertension) crisis.

Drug Interactions

Drug-Drug Interaction: Syncapone 50 Tablet 10’s may have interaction with other antiparkinson’s drugs (rasagiline, selegiline, pramipexole, apomorphine), medicines used to treat depression (moclobemide, amitriptyline, desipramine, maprotiline, venlafaxine, paroxetine, rimiterole, isoprenaline), medicines used to treat respiratory diseases or allergic reactions (adrenaline, noradrenaline) medicines used to treat high blood pressure (methyldopa)  water pills or diuretics (furosemide), high cholesterol-lowering drugs (atorvastatin), vitamins (pyridoxine), and anticonvulsants (phenytoin ), medicines used to relax the muscles (papaverine), dopamine D2 receptor blocker (metoclopramide, phenothiazines, butyrophenones, risperidone), antibiotics (erythromycin, rifampicin, ampicillin, chloramphenicol), a medicine used to treat TB (isoniazid).

Drug-Food Interaction: Syncapone 50 Tablet 10’s may interact with proteins in the food. Therefore, avoid intake of high protein food such as chicken, beef, pork, eggs, and fish as they may reduce the effectiveness of Syncapone 50 Tablet 10’s. Do not take vitamin supplements with Syncapone 50 Tablet 10’s unless prescribed by a doctor. Also, avoid alcohol intake as it may increase side effects such as drowsiness, dizziness, or difficulty in concentrating.

Drug-Disease Interaction: If you have glaucoma, asthma, nausea, dizziness, mental illness, breathing problems, daytime sleepiness, or involuntary muscle movements, inform your doctor before taking Syncapone 50 Tablet 10’s.