Domrab Capsule (Domperidone 30mg / Rabeprazole 20mg)

Medical Description

Domrab Cap contains combination of Rabeprazole and Domperidone, an anti-reflux medicine.

Uses of Domrab Capsule

It is used in the treatment of gastrointestinal reflux disease. This condition leads to acid regurgitating from the stomach into the food pipe, causing heartburn, chest discomfort and acidity.

Contraindications of Domrab Capsule

If you are allergic to this medicine or any of the ingredient of this medicine
If you are taking any medicine which might affect the contraction of heart muscle (QT prolongation)
If you are suffering from bleeding in the digestive system
If you are suffering from liver or kidney disorder
If you have serious heart problems like congestive heart failure, heart rhythm problems, electrolyte imbalance
If you have any tumor of the pituitary gland (Prolactin pituitary tumours)
If you are pregnant or breast feeding

Side effects of Domrab Capsule

Nausea
Headache
Lack of energy
Gas
Skin rash
Diarrhoea
Dry mouth
Stomach pain
Sleeplessness
Back pain
Throat infection (Pharyngitis)
Cough
Vomiting
Dizziness
Constipation
Breast pain and loss of sex drive

Other General Warnings

Talk to your doctor if
You develop watery diarrhoea, fever after taking this medicine
You experience black stools
You have a stomach tumour
You have a history of fractures or have osteoporosis or taking steroids
You have liver and kidney disease or kidney failure
You have heart problems and associated symptoms like palpitations, difficulty in breathing, unconsciousness
You are on this medicine for more than three months. Your blood magnesium levels may drop. Your doctor may perform regular tests for the same
You develop skin lesions especially in the sun exposed area after taking this medicine
You are taking medicines to treat HIV
You should not give this medicine to children of 12 years and below
You have low levels of vitamin B12. This medicine is known to reduce the absorption of vitamin B12 after long term use. Supplements may be needed
Taking this medicine for more than one year may increase chances of developing bone fractures

Mode of Action of Domrab Capsule

How Does It Work?
A pump called the proton pump in the stomach is responsible for the secretion of stomach acids. Rabeprazole binds to this proton pump in stomach cells, thus blocking acid secretion
Domperidone increases the motility of stomach and intestines so that acid does not reflux back into the food pipe

Directions for Use of Domrab Capsule

It should be taken as a whole with a sufficient amount of water (and should not be chewed or crushed), preferably in the morning before food.

Interactions of Domrab Capsule

Interactions with other medicines
There is limited information available on the interaction of this combination with other drugs. However, as this medicine contains Omeprazole and Domperidone, any interactions seen with these two components when taken alone may occur with this combination
Rilpivirine should never be used with this medicine
Never take these medicines along with it: Disopyramide, Amiodarone, medicines for mental problems haloperidol, Citalopram, antibiotics like Erythromycin, Levofloxacin, Azithromycin, antifungals like Pentamidine, Ketoconazole and other medicines like Cisapride, Dolasetron, Mequitazine etc.
This medicine interferes with the action of antiviral medicines like Rilpivirine, Atazanavir and Nelfinavir and antifungals like Posaconazole, Ketoconazole and Itraconazole
Medicine used to treat heart failure like digoxin may lead to toxicity when taken with this medicine
Medicines used for mental disorders like Diazepam, Phenytoin
If you are taking Warfarin, caution is needed as there are chances of increased bleeding
Interactions with food items
It should preferably be taken on an empty stomach
There are no known interactions with food or beverages
However, nicotine and caffeine (coffee, tea, chocolate and cola) can increase stomach acid or delay ulcer healing and hinder the treatment process

Storage and disposal of Domrab Capsule

Store below 25°C, protected from moisture and light
Keep the medicine out of the reach of children

Dosage of Domrab Capsule

Overdose
Symptoms of overdose include confusion, anxiety, fits, altered consciousness, sleepiness, etc.
If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital
Missed a Dose
If you missed any dose of the medicine take it as soon as you remember
If it’s time for your next dose, then skip the missed dose and continue with your regular dose schedule
Do not take a double dose of medicine to compensate for the missed one