ZOSYN 4000MG/500MG INJECTION (Piperacillin 4000mg / Tazobactum 500mg)

ZOSYN 4000MG/500MG INJECTION

Zosyn Injection is a combination of Piperacillin and Tazobactam. It is used for the treatment of bacterial infections that affect the lungs, urinary tract, skin, etc. This medication is effective only for the treatment of infections caused by bacteria and not viruses.

Zosyn Injection is effective against a large number of bacteria. Piperacillin works by preventing the formation of bacterial cell walls and killing the infection-causing bacteria. Tazobactam protects Piperacillin and ensures extended anti-bacterial activity.

Zosyn Injection may cause some common side effects such as diarrhoea, upset stomach, headache, sleeplessness, skin rash and itching, etc. Consult your doctor if these symptoms persist or if they become severe.

Zosyn Injection is given by your doctor in a clinic or a hospital setting. The dose and duration of the treatment will depend on your condition. Follow the instructions given by your doctor and continue receiving the medicine for the prescribed duration. Not completing the full course of therapy may result in decreased effectiveness of the medicine or an increased risk of re-infection that would be difficult to treat in the future.

Zosyn Injection is not recommended if you are allergic to it. This medicine is not advisable for children below 2 years of age. Inform your doctor if you have any kidney/liver problems or a history of seizures (fits) before starting treatment with this medicine. Consult your doctor if you are pregnant or are breastfeeding.

Side effects

Major & minor side effects for Zosyn Injection
Diarrhoea
Headache
Sleeplessness
Abdominal pain
Nausea and Vomiting
Stomach upset
Skin rash and itching
Fever
Injection site reactions (redness, pain, swelling)
Joint and muscle pain

Uses of Zosyn Injection

What is it prescribed for?
Community acquired pneumonia
Community-acquired pneumonia (CAP) refers to pneumonia (lung infection) that is acquired outside the hospital. CAP can be bacterial or viral. Zosyn Injection is used to treat CAP caused by bacteria Haemophilus influenzae.
Nosocomial Pneumonia or Hospital-acquired Pneumonia (HAP)
Nosocomial Pneumonia refers to pneumonia (lung infection) that is acquired in the hospital. Zosyn Injection is used to treat HAP caused by the bacteria Staphylococcus aureus, Haemophilus influenzae, Klebsiella pneumoniae, etc.
Urinary Tract Infection
Urinary Tract Infection is an infection in any part of your urinary system. It may affect your kidneys, bladder, or urethra. Symptoms may include increased urge to urinate, pain during urination, blood in the urine, back pain, nausea, vomiting, fever, etc. Zosyn Injection is used in the treatment of urinary tract infection.
Intra abdominal infection
Intra-abdominal infection is a broad term that includes a number of infections of the organs of the abdomen. It includes peritonitis (swelling of the lining of the abdominal wall), diverticulitis (swelling of diverticula- one or more small pouches in the intestine), cholecystitis (swelling of the gallbladder), cholangitis (swelling of the bile duct system), and pancreatitis (swelling of the pancreas). Zosyn Injection is used in the treatment of these infections.
Skin and Skin Structure Infection
Zosyn Injection is used in the treatment of skin and skin structure infections such as cellulitis (serious bacterial skin infection, usually affecting lower legs), cutaneous abscesses (skin infection with the presence of pus), and diabetic foot infections (foot infection due to diabetes) caused by bacteria Staphylococcus aureus.
Bacterial Septicaemia
Septicaemia, also known as blood poisoning is a serious infection of the blood. It occurs when a bacterial infection in any part of the body (such as the lungs or the skin) enters the bloodstream. Zosyn Injection is used in the treatment of bacterial septicaemia.
Neutropenia
Neutropenia is a condition with decreased number of neutrophils, a type of white blood cell that helps fight infections in your body. Neutropenia increases your risk of developing infections. Zosyn Injection is used in the treatment of fever associated with neutropenia.

When not to use?

Allergy
Avoid taking Zosyn Injection if you are allergic to it. Seek immediate medical attention if you notice any symptoms of allergic reactions such as skin rash, itching/swelling (especially of your face/tongue/throat), severe dizziness, breathing difficulty, etc.

Warnings

Warnings for special population
Pregnancy
Due to a lack of safety and efficacy studies in pregnant women, the risk to your developing foetus is not known. If you are pregnant, take Zosyn Injection only if prescribed by your doctor.
Breast-feeding
Zosyn Injection passes into breast milk in very low quantities and may cause diarrhoea in your breastfed infant. If you are breastfeeding, consult your doctor.
General warnings
Antibiotic resistance
Antibiotic resistance is a condition in which the antibiotic is not effective against the bacteria. This can be avoided by completing the entire course of treatment with Zosyn Injection as prescribed by your doctor.
Diarrhoea
Zosyn Injection can cause diarrhoea because it may also kill the helpful bacteria in your stomach or intestine. Get emergency medical help if you experience severe watery or bloody diarrhoea. Consult your pharmacist/doctor before taking anti-diarrhoeal medication.
Skin reactions
Zosyn Injection may cause allergic skin reactions. Inform your doctor if you experience any signs and symptoms of skin reaction such as skin rash, severe itching/swelling on your face/body.
Intravenous administration
Zosyn Injection is given as a slow intravenous infusion in a clinic/hospital setting.
Use in children
Zosyn Injection is not recommended for use in children below 2 years of age due to a lack of safety and efficacy data.
Seizures
Zosyn Injection should be given with caution if you have any pre-existing kidney problems or a history of seizures (fits) due to the increased risk of a seizure attack.
Bleeding problems
Zosyn Injection may increase your risk of bleeding. This risk is especially higher if you have any pre-existing kidney problems. Your doctor may recommend tests (prothrombin time) to monitor your bleeding problems.
Low white blood cell count
Zosyn Injection may increase your risk of leukopenia and neutropenia (decreased number of leukocytes and neutrophils, a type of white blood cells), especially with prolonged therapy. Your blood cell count will be closely monitored.
Driving or operating machinery
Zosyn Injection may cause sleeplessness. Do not drive or operate machines if you experience any symptoms that may affect your mental alertness.

Dosage

Missed Dose
Since Zosyn Injection is given by a qualified healthcare professional in the clinic/hospital setting, the likelihood of a missed dose is very low.
Overdose
Since Zosyn Injection is given in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low.

Interactions

General Instructions
Zosyn Injection is given by a qualified healthcare professional in a clinic/hospital setting. Follow all the instructions given by your doctor.

If you experience any redness/pain/swelling at the site of injection that becomes bothersome, inform your doctor immediately.

Zosyn Injection may lower your white blood cell count. Periodic monitoring of your blood cell count is recommended.

Zosyn Injection may increase your risk of seizures (fits). Inform your doctor if you have any history of seizures before starting treatment with this medicine.