Zostum 500 mg/500 mg Injection (Cefoperazone 500mg / Sulbactam 500mg)

Description

Zostum-500 Injection is a combination medicine which may be used to treat infections of the respiratory tract, urinary tract, bone and joints, intraabdominal infections, skin, and soft tissue infections, etc. caused by susceptible bacteria. This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects.

Side effects

Major & minor side effects for Zostum-500 Injection
Headache
Nausea and Vomiting
Diarrhea
Rash
Itching
Blood in urine
Decrease in blood cell count
Gastrointestinal side effects
Chills
Injection site Thrombophlebitis
Seizures
Injection site pain
Uses of Zostum-500 Injection
What is it prescribed for?
Urinary tract infections
This medicine is used in the treatment of upper and lower urinary tract infections caused by susceptible bacteria such as Escherichia coli, Pseudomonas aeruginosa, etc.
Respiratory Tract Infection
This medicine is used in the treatment of upper and lower respiratory tract infections caused by susceptible bacteria such as Staphylococcus aureus, Escherichia coli, Klebsiella species, Proteus mirabilis, Enterobacter species, etc.
Intra-abdominal Infections
This medicine is used in the treatment of intra-abdominal infections such as peritonitis, cholecystitis, cholangitis, etc. caused by susceptible bacteria such as Escherichia coli, Pseudomonas aeruginosa, etc.
Bacterial Septicemia
This medicine is used in the treatment of bacterial septicemia which is an infection of the blood that may be caused by bacteria such as Pseudomonas aeruginosa, Haemophilus influenzae, Escherichia coli, etc.
Skin and Soft tissue infections
This medicine is used in the treatment of skin and soft tissue infections caused by bacteria such as Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, etc.
Gynecologic infections
This medicine is used in the treatment of gynecologic infections such as endometritis, pelvic inflammatory disease, gonorrhea, etc. caused by susceptible bacteria such as Neisseria gonorrhoeae, Staphylococcus epidermidis, Streptococcus agalactiae, Escherichia coli, etc.

When not to use?

Allergy
This medicine is not recommended for use in patients with a known allergy to cefoperazone, sulbactam, other beta-lactam antibiotics, or any other inactive ingredients present along with these medicines.

Related product

Warnings

Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings
Kidney Disease
This medicine should be used with caution in patients with a known history of kidney impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Intravenous Use
When administered as an intravenous infusion, this medicine should be administered over a duration of 15 to 60 minutes. When administered as an intravenous injection, this medicine should be administered over a minimum of 3 minutes.
Drug resistance
Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and may even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.
Clostridium difficile-associated Diarrhea
Inform the doctor immediately in case of severe and persistent diarrhea. Antibiotic therapy will cause an imbalance in the normal microbial flora in the large intestine. This may decrease the gut-friendly bacteria and may promote the growth of a bacteria called Clostridium difficile, resulting in diarrhea. Appropriate corrective measures and replacement with a suitable alternative may be necessary based on the clinical condition.
Liver diseases
This medicine should be used with extreme caution in patients with a known history of liver diseases or active liver diseases due to the increased risk of serious adverse effects. Close monitoring of liver function is recommended for such patients. The dose of cefoperazone should not exceed 4 g/day for such patients unless specifically required and only with close monitoring of serum cefoperazone concentrations and liver function. In patients with liver and renal function impairment, the cefoperazone dose should not exceed 2 g/day.
Electrolyte imbalance
This medicine should be used with caution in patients with a known history of electrolyte imbalance since it may worsen the patient’s condition. Report any unusual symptoms to the doctor immediately. Close monitoring of electrolyte levels, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.
Epilepsy
This medicine should be used with caution in patients with a known history of epilepsy due to the increased risk of worsening of the patient’s condition. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Dosage

Missed Dose
Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low.
Overdose
Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

Interactions

General Instructions
This medicine should be administered by a qualified healthcare professional in the clinical or hospital setting. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Report any undesirable side effects to the doctor promptly.