Zoryl M 1 Forte Tablet (Glimepiride 1mg / Metformin 1000mg)

Medical Description

Zoryl M 1 Forte tablet is an anti-diabetic medicine used to lower the raised blood glucose levels in the blood when it is not being controlled by diet and exercise. This medicine is used to treat Type 2 diabetes mainly. It contains a combination of glimepiride and metformin as active ingredients. Take this medicine as prescribed by your doctor, preferably after meals. Zoryl M 1 Forte tablet should not be used in children below 18 years of age. Do not stop taking this medicine, as it can result in increased blood sugar levels and complications. Side effects of this medicine are disturbance, nausea, vomiting and diarrhoea. Mostly these side effects get resolved over a short time. If it worsens, reach out to the nearest clinic or hospital.

Uses of Zoryl M1 Forte Tab 15’S

Zoryl M 1 Forte tablet is used to treat type 2 diabetes mellitus; when diet, exercise and Glimepiride or Metformin alone is not able to control the blood sugar levels adequately.

Contraindications of Zoryl M1 Forte Tab 15’S

If you are allergic to metformin, glimepiride or any of the ingredients of the Zoryl M 1 Forte tablet.
If you are pregnant or breastfeeding.
If you have serious kidney failure or liver failure.
If you have any metabolic acidosis (too much acid in the body fluids) like lactic acidosis, diabetic ketoacidosis or diabetic pre-coma.
If you have dehydration, severe infections, shock and injections containing iodine.
If you have had heart or lung failure, the recent incidence of heart attack and shock.
If you are an alcoholic.

Side effects of Zoryl M1 Forte Tab 15’S

Weight gain, low blood sugar levels can cause headache, sweating, nausea, wet skin, anxiety and restlessness.
Vomiting, nausea, diarrhoea, stomach pain, loss of taste sensation, metallic taste and stomach discomfort (pressure and fullness).
High blood pressure, irregular heart rhythm, chest pain (arrhythmias), rash, itching, temporary visual disturbances.
Difficulty in breathing and decrease in vitamin B12 levels.

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Other General Warnings

Talk to your doctor if
You experience extreme hunger, headache, nausea, vomiting, sleepiness, restlessness, aggression, reduced alertness, confusion, shakiness or dizziness. These could be signs of low blood sugar. If you have any of these, immediately have sugar or sweet juice. Inform your doctor as you may need a change in your medicine’s dose.
You are experiencing pins-and-needles sensation, numbness and weakness.
You are going to have a diagnostic imaging test that involves the injection of iodine.
You have dehydration due to diarrhoea, vomiting or limited fluid intake.
You have suffered through trauma.
You have to undergo surgery shortly. You have serious kidney and liver problems. You have a thyroid disorder.
You are overweight (specific diet restriction may be suggested).

Mode of Action of Zoryl M1 Forte Tab 15’S

How Does It Work?
Zoryl M 1 Forte tablet is known to control blood sugar to a greater extent than metformin or glimepiride alone. Glimiperide lowers the blood sugar level increasing release of insulin hormone from the pancreas.
Insulin moves sugar (glucose) from the blood into the cells.
Metformin decreases the absorption in the intestine and the production of sugar by the liver.
Both of these components are known to increase the insulin sensitivity of the body (which allows the cells of the body to use blood glucose more effectively, reducing blood sugar).

Directions for Use of Zoryl M1 Forte Tab 15’S

Zoryl M 1 Forte tablet should be taken as directed by your doctor. Swallow it whole with a glass of water. Take it at a fixed time for optimal results. Do not consume it more than that prescribed by your doctor.

Interactions of Zoryl M1 Forte Tab 15’S

Interactions with other medicines
Sometimes Zoryl M 1 Forte tablet may affect the way other medicines work and other medicines may affect how Zoryl M 1 Forte tablet works if taken at the same time.
Always inform your doctor about all the medicine you are taking, which includes all prescribed or non-prescribed herbal medicines, dietary supplements as well as other treatments if you are taking for any disorder.
Especially if you are on certain medications like painkillers, medicines for heart diseases, muscle pain, brain-related disorder, antacids like ranitidine, anti-coagulants such as warfarin, medicine to lower blood cholesterol (fibrates), medicines for a thyroid disorder, antihypertensive medicines, etc.
Other medicines that should be used with caution are antibiotics like Clarithromycin, oral contraceptives, anti-epileptic medicines like phenytoin, medicines for constipation, water pills, etc.
You may have symptoms of low blood sugar if you are already taking other medicines for diabetes like Insulin, Pioglitazone. Caution is advised.

Storage and disposal of Zoryl M1 Forte Tab 15’S

Store at room temperature in a dry place.
Protect it from light and moisture.
Keep it out of the reach of children.

Dosage of Zoryl M1 Forte Tab 15’S

Overdose
Overdose of Zoryl M 1 Forte tablet may lead to severe hypoglycemia (low blood sugar) and lactic acidosis (excessive lactic acid build-up).
This can result in headache, nausea, vomiting, sleep disturbances, restlessness, impaired alertness and reactions, depression, confusion, dizziness, etc.
If you experience these, immediately take glucose or juice or sugar-containing products (sugar candy).
Contact your doctor immediately or visit the nearest hospital as you may require close monitoring for the next few hours.
Missed a Dose
A missed dose may lead to high blood sugar levels, which includes symptoms like feeling thirsty, excessive urination, loss of appetite, drowsiness, the fruity smell from breath, etc.
If you missed any dose of medicine, take it as soon as you remember.
If it’s time for your next dose, then skip the missed dose and continue with your regular dose schedule.
Do not take a double dose of medicine to compensate for the missed one.