Topaz 50 Tablet (Topiramate 50mg)

INTRODUCTION

TOPAZ 50MG contains Topiramate which belongs to a group of medicines called anti-epileptic medicines. It is used to treat seizures in both adults as well as in children. It can also be used to prevent migraine headaches in adults. A seizure is a sudden, uncontrollable electrical changes or disturbance in your brain. It may cause changes in behavior, movements or feelings and in levels of consciousness. Topiramate prevents the occurrence of seizures and prevents migraine symptoms by reducing neural pathway excitability.

You might shed your weight if you use topiramate continuously. If you are losing too much weight, you should consult your doctor. You can take topiramate with or without food. Drink plenty of fluids during the day to prevent kidney stones while taking topiramate tablets. You should avoid drinking alcohol when taking topiramate tablet. This medicine can harm an unborn baby. So, it is not recommended for use in pregnant women. Mothers who breastfeed while taking TOPAZ 50MG, must tell the doctor as soon as possible if the baby experiences anything unusual.

USES OF TOPAZ 50MG

Treat seizures in adults and children
Prevent migraine headaches in adults

HOW TOPAZ 50MG WORKS

Topiramate stimulates GABA-A receptor activity at brain, a non-benzodiazepine receptor sites and reduces glutamate activity at both AMPA and kinate receptors. By increasing GABA activity and inhibiting glutamate activity, topiramate blocks neuronal excitability, preventing seizures and migraine.

DIRECTIONS FOR USE

Always take this medicine as directed by your physician. It can be taken before, during, or after a meal. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine. Your doctor will decide the dose and duration of the therapy depending upon your age, weight and condition. To prevent kidney stones, drink plenty of fluids during the day.

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SIDE EFFECTS OF TOPAZ 50MG

SERIOUS
Depression (new or worse)
Seizures (fits)
Anxiety, irritability, changes in mood, confusion, disorientation
Problems with concentration, thinking and memory
Kidney stone, frequent or painful urination
Increased acid level in the blood (shortness of breath, loss of appetite, nausea, vomiting, excessive tiredness, and fast or uneven heart beats)
Having thoughts of serious self-harm
Glaucoma or inflammation in the eye
COMMON
Weight loss
Anemia
Dizziness
Nausea or vomiting
Diarrhea, constipation, bloating, abdominal pain
Allergic reaction such as skin redness, rash, itching, facial swelling, hives
Difficulty in sleeping
Slurred speech, blurred vision, vertigo, ringing in the ears
Lack of coordination when walking
Impaired sense of taste and touch
Hair loss
Joint pain, muscle pain, chest pain
Psychosis (severe mental disorder)
Slow or irregular heartbeat, low blood pressure,
Pancreatitis (inflammation of the pancreas)
Learning disability
RARE
Loss of consciousness
Night blindness
Abnormal skin odour

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after, a meal. Stick to simple meals. Do not eat rich or spicy food.

Constipation:

Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.

Diarrhea:

Drink lots of fluids, such as water or squash, to avoid dehydration. Do not take any other medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

WARNING & PRECAUTIONS

PREGNANCY
TOPAZ 50MG should be used with caution in pregnant women. Consult your doctor before taking this medicine.

BREASTFEEDING
TOPAZ 50MG should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.

DRIVING AND USING MACHINES
Do not drive or operate any tools or machines if your ability is affected by this medicine.

ALCOHOL
Avoid consumption of alcohol while taking this medicine.

KIDNEY
TOPAZ 50MG should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.

LIVER
TOPAZ 50MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice.

ALLERGY
Do not take this medicine if you are allergic to topiramate or any other ingredients in this medicine.

OTHERS

Talk to your doctor before taking this medicine, if you:

Have metabolic acidosis (blood and body fluid abnormality), glaucoma, growth problem, are on a high fat diet (ketogenic diet)

INTERACTIONS

Talk to your doctor, if you are taking,

Birth control pills
Other medicines used to treat epilepsy (e.g. carbamazepine or phenytoin)
Medicines used to treat depression (e.g. risperidone, lithium, amitriptyline, venlafaxine, St John’s Wort)
Warfarin (used to thin the blood)
Medicines used to treat angina and high blood pressure (e.g. hydrochlorothiazide, propranolol or diltiazem)
Medicines used to treat diabetes (e.g. metformin, pioglitazone, glibenclamide)
Flunarazine (used to treat migraine)
Digoxin (used for heart problems)
Haloperidol (used for mental health problems)
Proguanil (used to treat malaria)
Omeprazole (used to treat stomach acid)