Tenvir Tablet (Tenofovir disoproxil fumarate 300mg)

INTRODUCTION

TENVIR contains tenofovir disoproxil fumarate which is an antiretroviral or antiviral medicine. It is a nucleotide reverse transcriptase inhibitor, generally known as an NRTI and works by interfering with the normal working of enzymes (in HIV reverse transcriptase; in hepatitis B DNA polymerase) that are essential for the viruses to reproduce themselves. It is used with other antiviral medicines to treat Human Immunodeficiency Virus (HIV) in adults and children 2 years of age and older. HIV is the virus that causes the AIDS (Acquired Immune Deficiency Syndrome).

It is also used to treat chronic hepatitis B virus infection [HBV]. Take this medicine at the same time every day. For adults, the usual dose of this medicine is one 300 mg tablet each day or as directed by physician. If you have kidney problems, your healthcare provider may tell you to take TENVIR. It is not recommended for pregnant or breastfeeding. Before taking, tell your doctor if you have liver, kidney or heart problems. Do not drive or operate any machinery while taking this medicine, it may make you feel dizzy. The common side effects are diarrhea, vomiting, nausea, dizziness, rash, feeling weak.

USES OF TENVIR

Treat in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older
Treat chronic hepatitis B, an infection with HBV (hepatitis B virus)

HOW TENVIR WORKS

TENVIR may help to increase the number of CD4 (T) cells in your blood which help fight off other infections. Reducing the amount of HIV and increasing CD4 (T) cell count may improve your immune system. This may reduce the risk of death or infections that can happen when your immune system is weak (opportunistic infections).

DIRECTIONS FOR USE

The recommended dose of this medicine is one 300 mg tablet each day or as directed by physician. Swallow the medicine whole with plenty of water.

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SIDE EFFECTS OF TENVIR

SERIOUS
Severe liver problems such as jaundice, dark “tea-colored” urine, light-colored bowel movements (stools) and loss of appetite
COMMON
Headache
Diarrhoea
Vomiting and nausea
Dizziness
Stomach pain
Rash
Joint pain (arthralgia)
Rash, itchiness
Feeling bloated

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Keep try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.

Headache:

Rest and drink plenty of fluids. Apply a cold, wet cloth or ice pack to your forehead. Rest in a quiet, comfortable, dark room.

Rash:

Avoid bathing with hot water because hot water can irritate the skin. Moisturizers can be used regular basis to soothe and hydrate the affected area.

Diarrhea:

Drink lot of fluid, such as water or squash, to avoid dehydration. Do not take any other medicine without consulting your doctor.

WARNING & PRECAUTIONS

PREGNANCY
TENVIR should be used with caution in pregnant women. Consult your doctor before taking this medicine.

BREASTFEEDING
TENVIR should be used with caution for breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES
Do not drive or operate any machinery while taking this medicine, it may make you feel dizzy.

ALCOHOL
Avoid consumption of alcohol while taking this medicine.

KIDNEY
TENVIR should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.

LIVER
TENVIR should be taken with caution in patients with severe liver disease. Consult your doctor for advice.

ALLERGY
Do not take if you are allergic to the medicine.

OTHERS

Before you take this medicine, tell your doctor if you have bone problems.

INTERACTIONS

Talk to your doctor if you are taking:

Medicines used to treat bacterial infections including tuberculosis, containing rifabutin, rifampicin or rifapentine
Medicines used to treat the HIV, such as ritonavir or cobicistat boosted darunavir, lopinavir or atazanavir
Anticonvulsants used to treat epilepsy, such as carbamazepine, oxcarbazepine, phenobarbital or phenytoin
Herbal remedies used to treat the depression and anxiety, containing St. John’s wort (Hypericum perforatum)