Synthivan Tablets (Atazanavir 300mg / Ritonavir 100mg)

Description

Synthivan Tablet is a combination of Atazanavir and Ritonavir. It is an antiviral medicine used for the treatment of human immunodeficiency virus (HIV) infection (a condition that occurs when the virus attacks the immune system and interferes with your body’s ability to fight infections or diseases).

Synthivan Tablet will not cure HIV infection, but it will delay the progression of a chronic, potentially life-threatening condition known as acquired immunodeficiency syndrome (AIDS) and other HIV-related conditions. This medicine works by preventing the virus from multiplying.

Synthivan Tablet shows some side effects like nausea, vomiting, stomach pain, diarrhoea, headache, heartburn, dizziness, drowsiness, change in taste, weakness, trouble sleeping, etc. Consult your doctor if they bother you for a longer time or worsen. Do not take this medicine if you are allergic to it.

Synthivan Tablet should be taken with food. Take it in the dose and duration prescribed by your doctor. Do not take more than the recommended dose. Take it every day at the same time to maintain a consistent level of this medicine in your blood. Do not discontinue this medication without consulting your doctor, as it may worsen your condition.

Synthivan Tablet may not be suitable for everyone. Inform your doctor if you have heart, liver, or kidney problems, diabetes (high blood sugar levels), or any other health conditions. Also, inform your doctor about all your ongoing medications to avoid undesired effects.

Synthivan Tablet is unsafe for use during pregnancy. Consult your doctor if you are breastfeeding. If you have an HIV infection, it is not recommended to breastfeed, as the Human immunodeficiency virus (HIV) may transfer to the baby through breastmilk.

Side effects

Major & minor side effects for Synthivan Tablet
Redness of the skin especially on the face and neck
Headache
Weight change
Confusion
Acid or sour stomach
Change in sense of taste
Sleepiness or unusual drowsiness
Mood or mental changes
Tender, swollen glands in the neck
Skin Rash
Sweating
Stomach pain
Diarrhoea
Dry mouth
Nausea and Vomiting
Weakness
Heartburn

Uses of Synthivan Tablet

What is it prescribed for?
HIV infection
HIV infection is caused by the human immunodeficiency virus (HIV). The virus attacks the immune system of your body and affects your body’s disease-fighting ability. It can be transmitted through infected blood, semen, and vaginal fluid. The symptoms include fatigue, weight loss, fever, night sweats, and recurrent infections. Synthivan Tablet is used in the treatment of human immunodeficiency virus (HIV) infection.

When not to use?

Allergy
Avoid taking Synthivan Tablet if you are allergic to it. Serious allergic reactions to this medicine are rare. However, seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.
Drug interaction
CYP3A or UGT1A1 are liver enzymes responsible for the breakdown of various medicines such as Alfuzosin, Amiodarone, Rifampin, Irinotecan, Triazolam, Midazolam, Cisapride, Simvastatin, Lovastatin, Indinavir, Sildenafil, Voriconazole, Ranolazine, Lurasidone, Pimozide, Colchicine, Ergotamine, etc., in the liver. Synthivan Tablet is not recommended for use if you are receiving medicines that are highly dependent on CYP3A or UGT1A1 enzymes for their breakdown in the liver. Combined use may increase the risk of alteration in the blood levels of these medications, which may cause serious and life-threatening reactions.
Moderate to severe live impairment
Synthivan Tablet is not recommended for use if you have moderate to severe liver problems, as this medicine may cause liver toxicity and further worsen your condition.

Warnings

Warnings for special population
Pregnancy
Synthivan Tablet may be used during pregnancy if clearly needed. If you are pregnant, consult your doctor to understand the potential risks and benefits of taking this medicine.
Breast-feeding
Synthivan Tablet is not recommended for use while breastfeeding. Also, women with HIV infection are not recommended to breastfeed as the Human immunodeficiency virus (HIV) can be passed to the baby through breastmilk.
General warnings
Fat Redistribution
Synthivan Tablet should be used with caution as it may cause fat gain or fat loss in the body. It may result in central obesity, buffalo hump (excess fat behind the neck), peripheral wasting (difficulty in moving an arm or leg or making any movement), facial wasting (fat loss in the cheeks and temples), breast enlargement, and cushingoid appearance (extra fat build up on the sides of the face and weight gain). Consult your doctor if you have any concerns.
Pancreatitis
Pancreatitis refers to the swelling of the pancreas, a gland that produces chemical substances which help in digestion and regulation of blood sugar. Synthivan Tablet should be used with caution as it may cause pancreatitis. The risk is especially higher if you have a history of pancreatitis.
Immune reconstitution syndrome
Changes in your immune system can occur when you start taking Synthivan Tablet. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. It may cause an exaggerated response making the symptoms of infection worse. Inform your doctor if you develop any new symptoms after starting treatment with Synthivan Tablet.
Nephrolithiasis and Cholelithiasis
Synthivan Tablet should be used with caution as it may cause Nephrolithiasis (kidney stones) and/or Cholelithiasis (gallstones).
Increase in cholesterol and fats levels
Synthivan Tablet should be used with caution as it may cause an increase in cholesterol and fats levels in the blood. Your doctor may suggest tests to periodically monitor your lipid (fats) levels in the blood while you are taking this medicine.

Dosage

Missed Dose
Take the missed dose of Synthivan Tablet as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
Overdose
Never take more than the prescribed dose. Contact your doctor in case of an overdose of Synthivan Tablet.

Interactions

General Instructions
Take Synthivan Tablet exactly as instructed by your doctor.

Do not take in larger or smaller quantities than recommended.

Your doctor may suggest tests to monitor your liver function and lipid (fats) levels during treatment with this medicine.

This medicine may cause redistribution and accumulation of body fat in different parts of your body, such as below your neck, upper back, breasts, or around the stomach. It may also cause loss of body fat from your legs, arms, and face. Consult your doctor if you have any concerns.