Plagerine Tablet (Clopidogrel 75mg)

INTRODUCTION

PLAGERINE 75MG contains Clopidogrel which belongs to a group of medicines called antiplatelet which prevents the clumping and reduces the formation of blood clots (thrombosis). Platelets are very small structures in the blood which clump together during blood clotting. This medicine is used to prevent blood clots in conditions such as atherosclerosis, where the arteries are hardened, unstable angina or heart attack and irregular heartbeat.

It works by preventing platelets from clumping together and forming clots. It binds irreversibly to the P2Y12 class of adenosine diphosphate (ADP) receptors on platelets and inhibits their clumping. This prevents the formation of blood clots and thus lowers the risk of heart attack or stroke. Before taking this medicine inform your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding.

PLAGERINE 75MG is not suitable for use in children. Your doctor will give the correct dose depends on your age, body weight and health condition. The most common side effects is bleeding. Do not take if you had bleeding disorder or have stomach ulcer or bleeding within the brain.

USES OF PLAGERINE 75MG

Prevent blood clots in conditions such as atherosclerosis, unstable angina or myocardial infarction (heart attack) and atrial fibrillation (irregular heartbeat)

HOW PLAGERINE 75MG WORKS

Clopidogrel works by preventing platelets from clumping together and forming clots and lowers heart attack or stroke.

DIRECTIONS FOR USE

Always take this PLAGERINE 75MG as instructed by your doctor. Swallow as a whole and do not crush or chew. Do not exceed the recommended dose. Your doctor will give the right dose depends on your condition. It may be taken with or without food.

SIDE EFFECTS OF PLAGERINE 75MG

SERIOUS
Fever, infection or extreme tiredness
Yellowing of the skin or the eyes (jaundice)
Bleeding appears under the skin as red pinpoint dots and confusion
Swelling in the mouth
Rashes, itching, blisters of the skin
COMMON
Bleeding (stomach, bowels, haematoma, nose bleed, urine, eye, inside the head, lungs and joints)
RARE
Vertigo
Enlarged breasts in males

WARNING & PRECAUTIONS

PREGNANCY
PLAGERINE 75MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING
PLAGERINE 75MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES
PLAGERINE 75MG is unlikely to affect your ability to drive or to use machines.

KIDNEY
PLAGERINE 75MG should be used with caution in patients with active kidney diseases. Consult your doctor for advice.

LIVER
PLAGERINE 75MG is not recommended in patients with active liver diseases. Consult your doctor for advice.

ALLERGY
Do not take if you are allergic (hypersensitive) to clopidogrel.

HEART DISEASE
PLAGERINE 75MG should be used with caution if you had heart attack, irregular heart beat or any other heart diseases. Consult your doctor for advice.

OTHERS

Inform your doctor before taking this medicine, if you have or had,

Stomach ulcer or bleeding within the brain
Bleeding inside any tissues, organs or joints of your body
Recent injury or surgery
Clot in an artery of brain

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

Heparin, ticlopidine and oral anticoagulants (used to reduce blood clotting)
Non-steroidal anti-inflammatory medicine (treat painful and inflammatory conditions of muscle or joints)
Fluoxetine, moclobemide and fluvoxamine (treat depression)
Omeprazole, esomeprazole (treat upset stomach)
Fluconazole, voriconazole (treat fungal infections)
Efavirenz (treats HIV infections)
Carbamazepine (treats epilepsy)
Repaglinide (used to treat diabetes)
Paclitaxel (used to treat cancer)