Met XL AM 25/2.5 Tablet (Amlodipine 2.5mg / Metoprolol Succinate 23.75mg)

What is MET XL AM 25/2.5MG?

MET XL AM 25/2.5MG is the combination of Amlodipine Besylate (calcium channel blockers) and Metoprolol Tartarate (Beta blockers)

What MET XL AM 25/2.5MG is used for?

It is used in the treatment of hypertension and angina pectoris
It prevents death due to heart attacks

Warning & Precautions

Talk to your doctor before taking this medicine If you

Are allergic to MET XL AM 25/2.5MG
Suffer with heart conduction or rhythm problems, heart failure, blocked blood vessels
Suffer from a tight, painful feeling in the chest in periods of rest (Prinzmetal’s angina)
Are suffering from narrowing of the aortic heart valve (aortic stenosis)
Suffer with untreated phaeochromocytoma (high blood pressure due to a tumor near the kidney)
Suffer from increased acidity of the blood (metabolic acidosis)
Have low blood pressure
Have or have had breathing difficulties or asthma including COPD
Suffer with diabetes associated with frequent episodes of low blood sugar (hypoglycaemia)
Have liver or kidney disease or failure
Have difficulties in passing urine
Have low levels of potassium (hypokalaemia) or sodium (hyponatraemia) in your blood
Have high levels of calcium (hypercalcaemia)
Suffer with gout due to high levels of uric acid
Have or have suffered from psoriasis (severe skin rashes)
Have myasthenia gravis
Are going to have an operation or an anaesthetic, please tell your doctor that you are taking MET XL AM 25/2.5MG tablets, as your heart beat might slow down too much

Interactions

Do not take MET XL AM 25/2.5MG if you are already taking:

Other antihypertensives as injection especially verapamil, diltiazem or disopyramide.
Monoamine Oxidase Inhibitors (MAOIs) for depression
Cimetidine (to treat stomach ulcers)
Hydralazine, Clonidine or Prazosin (to treat high blood pressure)
Amiodarone and Propafenone (for irregular heart rhythm)
Tricyclic or SSRI antidepressants (to treat depression)
Barbiturates (to treat epilepsy)
Phenothiazines (for mental illness)
Anaesthetics such as cyclopropane or trichloroethylene
Aldesleukin (to treat some cancers, particularly cancer of the kidney)
Alprostadil (to treat erectile dysfunction)
Anxiolytics or hypnotics (e.g. temazepam, nitrazepam, diazepam)
Indometacin or celecoxib (Non-Steroidal Anti-Inflammatory Drugs (NSAIDs))
Rifampicin (antibiotic) or Terbinafine or Ketoconazole and Itraconazole (antifungal)
Cocaine
Corticosteroids (e.g. hydrocortisone, prednisolone)
Other beta-blockers e.g. eye drops.
Adrenaline (epinephrine) or Noradrenaline (norepinephrine), used in anaphylactic shock or other sympathomimetics
Medicines used to treat diabetes
Lidocaine (a local anaesthetic)
Moxisylyte (used in Raynaud’s syndrome)
Mefloquine (to treat malaria)
Tropisetron (to prevent nausea and vomiting)
Xanthines such as Aminophylline or Theophylline (to treat asthma)
Medicines to treat migranes such as Ergotamine
Cardiac glycosides e.g. Digoxin (to treat heart conditions)
Hydroxychloroquine (to treat rheumatoid arthritis)
Diphenydramine (sedative antihistamine).
HIV-protease-inhibitors (e.g. ritonavir)
Clarithromycin, erythromycin and telithromycin, rifabutin (antibiotics)
Nefazodone (medicine to treat depression)
John’s wort (Hypericum perforatum; herbal medicine for depression)
Dantrolene (infusion for severe body temperature abnormalities)
Tacrolimus (medicine used to alter the way your immune system works)
Simvastatin (cholesterol lowering medicine)
Cyclosporine (an immunosuppressant)

Directions & For Use

Always take this medicine exactly as your doctor has told you
You should check with your doctor or pharmacist if you are not sure
Swallow the medicine with a glass of water
High blood pressure

Initially 100mg metoprolol tartrate daily. The dose may be increased to 200mg daily in single or divided doses
Angina

50-100mg metoprolol tartrate two or three times daily
Irregular heartbeats (arrhythmia)

50mg metoprolol tartrate two or three times daily. The dose may be increased to 300mg daily in divided doses
Heart attacks

50mg metoprolol tartrate every six hours. The usual maintenance dose is 200mg daily in divided doses. The medicine should be taken for at least 3 months
If you take more MET XL AM 25/2.5MG

If you or someone else has taken too much MET XL AM 25/2.5MG, contact your nearest hospital casualty department
If you forget to take MET XL AM 25/2.5MG

If you forget to take a dose, take it as soon as you remember, unless it is nearly time for your next dose. Do not take a double dose to make up for a forgotten dose
If you stop taking MET XL AM 25/2.5MG

Do not suddenly stop taking this medicine as this may cause worsening of heart failure and increase the risk of heart attack. Only change the dose or stop the treatment in consultation with your doctor

Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Allergic reaction such as itching, difficulty breathing or swelling of the eyelids, face, lips, throat or tongue
Sudden wheeziness, chest pain, shortness of breath or difficulty in breathing
Severe skin reactions including intense skin rash, hives, reddening of the skin over your whole body, blistering, peeling and swelling of the skin, inflammation of mucous membranes (Stevens johnson syndrome) toxic epidermal necrolysis
Heart attack, abnormal heart beat
Inflamed pancreas which may cause severe abdominal and back pain accompanied with feeling very unwell
Tiredness, dizziness, headache, sleepiness
A slow heart rates
Feeling faint on standing due to low blood pressure
Shortness of breath with or without strenuous physical activity
Feeling or being sick
Stomach pain or stomach upset
Oedema (fluid retention)
Palpitations (awareness of your heart beat), flushing
Abdominal pain, feeling sick(nausea)
Altered bowel habits, diarrhoea, constipation, indigestion
Visual disturbances, double vision
Muscle cramps
Swollen ankles

Enlarged breasts or discomfort in men
Sleep disorders, irritability, depression, mood changes, anxiety
Pain, feeling unwell, dry mouth, uncontrolled shaking, pins and needles, increased sweating
Problems with your eye-sight (visual disturbances)
Trembling, taste abnormalities
Numbness or tingling sensation in your limbs, loss of pain sensation
Sneezing/running nose caused by inflammation of the lining of the nose (rhinitis)
Disorder in passing urine, increased need to urinate at night, increased number of times of passing urine
Ringing or buzzing in the ears
Fainting, increased heart rate, chest pain, muscle cramps, back pain, muscle and joint pain aggravation of angina may occur at the beginning of the treatment
Low blood pressure, inflammation of the blood vessels
Breathing difficulties, inflammation of the nasal mucosa, cough
Dry mouth, vomiting (being sick), diarrhoea, constipation, swollen gums
Prickling and tingling sensation of the skin, itching, red patches on skin, nettle rash, hair loss, discoloration of the skin
Increase or decrease in weight

Storage

Store at room temperature (15-25°C)
Protect from light
Do not take this medicine after the expiry date
Keep out of the reach of children