Esomac D 40 Capsule (Domperidone 30mg / Esomeprazole 40mg)

Medical Description

Esomac D 40mg Capsule contains a combination of two medicines – Esomeprazole and Domperidone. It is an anti-reflux medicine and is used to treat gastroesophageal reflux disease (GERD), which does not respond to esomeprazole medication alone. GERD is a condition in which acid from the stomach comes back up to the food pipe and causes heartburn, belching, nausea, and chest pain. It works by decreasing the amount of acid produced in the stomach and improves the mortality in the gut. Thus, it reduces the backflow of stomach content to the food pipe. Take this medicine as per the prescribed duration. It should preferably be taken at least an hour before the meal. Do not stop taking this medicine without informing your doctor. Headache, dizziness, nausea, diarrhoea, stomach pain, weakness, skin rash, dry mouth are some side effects that you may experience after taking this medicine. Most of which are temporary but if you feel the side effects persist or your condition worsens, you should contact your doctor immediately. This medicine is not recommended for use in patients below 18 years old.

Uses of Esomac D 40mg Capsule

Esomac D 40mg Capsule is used in adult patients to treat gastroesophageal reflux disease (GERD) in which there is a reflux of acid from the stomach into the food pipe, causing heartburn, chest discomfort, and acidity. It is particularly useful when GERD is not responding to esomeprazole medicine alone.

Contraindications of Esomac D 40mg Capsule

If you are allergic to Esomeprazole or Domperidone or any other ingredients of Esomac D 40mg Capsule.
If you have a blockage or tear in the intestines.
If you are suffering from liver or kidney disorder.
If you are suffering from bleeding in the digestive system.
If you have any tumour of the pituitary gland (Prolactin pituitary tumours).
If you have severe heart problems such as congestive heart failure, heart rhythm problems, electrolyte imbalance.
If you are taking any medicine which might affect the contraction of the heart muscle (QT prolongation).
If you are taking medicines such as Nelfinavir (used in HIV infection), Clarithromycin (antibiotic), Ketoconazole (antifungal) or Verapamil (used in high blood pressure and chest pain).

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Side effects of Esomac D 40mg Capsule

Headache, dizziness
Nausea, vomiting
Stomach pain, gas
Diarrhoea, constipation
Weakness, tingling feeling
Drowsiness, vertigo
Skin rash, itching
Swelling of the feet and ankles
Dry mouth
Insomnia, anxiety
Blurred vision (rare)

Other General Warnings

Talk to your doctor if
You have any liver and kidney-related diseases.
You have a specific blood test (Chromogranin A).
You experience black stools or have stomach tumour.
You have a history of fractures or have osteoporosis or taking steroids.
You develop skin lesions, especially in the sun-exposed area after taking this medicine.
You are taking medicines to treat HIV or apomorphine (used to treat muscle stiffness).
You have heart problems and associated symptoms like palpitations, difficulty in breathing, and unconsciousness.
You experience stomach pain or indigestion, unexplained weight loss, have problems while swallowing, vomit out food or blood after taking this medicine.
You have low levels of vitamin B12. This medicine is known to reduce the absorption of vitamin B12 after long term use. Supplements may be needed.
You are on these capsules for long-term treatment (more than three months), your blood magnesium levels may decrease. Hence, your doctor may perform regular tests for the same.
This medicine is not recommended for patients below the age of 18 years.
Taking this medicine for more than one year may increase the chances of developing bone fractures.
This medicine may lead to a slightly increased risk of bacterial infections due to Salmonella and Campylobacter.

Mode of Action of Esomac D 40mg Capsule

How Does It Work?
A pump called the proton pump in the stomach is responsible for the flow of stomach acids.
Esomeprazole works by binding to this proton pump in stomach cells and blocks the acid secretion.
Domperidone acts by increasing the motility of the stomach and intestines so that acid does not reflux back into the food pipe.

Directions for Use of Esomac D 40mg Capsule

This medicine should be taken at least 1 hour before meals. These capsules should be swallowed whole with water. These capsules should not be opened, chewed, or crushed. You should take this medicine regularly at a fixed time and as directed by your doctor. Do not consume it more than the prescribed dose.

Interactions of Esomac D 40mg Capsule

Interactions with other medicines
There is limited information available on the interaction of this medicine with other medicines. However, as this pill contains Esomeprazole and Domperidone, and any interactions with these two components when taken alone, may occur with this combination.
This medicine should not be taken concomitantly along with medicines such as Nelfinavir (used to treat HIV infection), Amiodarone (used to treat muscle stiffness), Clarithromycin (antibiotic), Ketoconazole (antifungal) or Verapamil (used in high blood pressure, chest pain).
This capsule should also not be taken along with medicines used to treat heart problems (Quinidine, Sotalol), psychiatric illness (Haloperidol, Citalopram), antifungals (Pentamidine), antimalarials (Halofantrine, Lumefantrine), medicines used to treat allergies (Mizolastine), medicines to treat in cancer (Toremifene, Vandetanib), gastric emptying medicines (Cisapride) and other medicines like Diphemanil and Methadone.
Concomitant use of this capsule with medicines used to treat psychiatric illness (Diazepam), used to treat fits (Phenytoin) is not recommended as it may increase the side effects of the medicines.
Medicine used to treat heart failure like Digoxin may lead to toxicity when taken with this medicine.
If you are taking Warfarin (blood-thinner) along with this medicine, caution is needed as there are chances of increased bleeding.
Other medicines like Rifampicin, Methotrexate, Tacrolimus, Voriconazole, Cilostazol, Clopidogrel, Azithromycin, St John’s wort, etc. should be used cautiously along with Esomac D 40mg Capsule.
Interactions with food items
This medicine should preferably be taken on an empty stomach at least 1 hour before meals.

Storage and disposal of Esomac D 40mg Capsule

Store this medicine below 25°C in a clean and dry place, protected from direct sunlight, moisture, and heat. Keep this medicine away from children and pets. Discard expired medicines or any unused medicine properly, do not flush in the toilet or throw it into the drain.

Dosage of Esomac D 40mg Capsule

Overdose
The symptoms of overdose include nausea, vomiting, indigestion, diarrhoea, constipation, weakness, confusion, agitation, anxiety, fits, altered consciousness, sleepiness, etc. In case of an overdose, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
If you miss any dose of this medicine, take it as soon as you remember. If it’s time for your next dose, skip the missed dose and continue with your regular dose schedule. Do not take a double dose of this medicine to compensate for the missed one. Skipping doses or not finishing the full course of therapy may reduce the effectiveness of the treatment.