Bevatas 100 Injection (Bevacizumab 100mg)

INTRODUCTION

BEVATAS 100MG contains Bevacizumab which belongs to a group of medicines called antiangiogenic agents. It is indicated to treat metastatic colorectal cancer, first-line non-squamous non small cell lung cancer, recurrent glioblastoma (GBM), metastatic renal cell carcinoma, persistent, recurrent, or metastatic cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer and hepatocellular carcinoma.

Bevacizumab is a humanized monoclonal IgG1 antibody which contains human framework regions and murine complementarity determining regions. This binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. This interaction of VEGF with its receptors leads to endothelial cell proliferation and new blood vessel formation in invitro models of angiogenesis. Bevacizumab reduces microvascular growth and inhibition of metastatic disease progression.

Before receiving this BEVATAS 100MG, tell your physician if you have liver, kidney or heart problems, are pregnant or breastfeeding. This medicine is not suitable for use in children and adolescents below 18 years of age. The common side effects are nose or rectal bleeding, headache, back pain or increased blood pressure.

USES OF BEVATAS 100MG

Treats,

• Metastatic colorectal cancer
• First-line non-squamous non small cell lung cancer
• Recurrent glioblastoma (GBM)
• Metastatic renal cell carcinoma
• Persistent, recurrent, or metastatic cervical cancer
• Epithelial ovarian
• Fallopian tube, or primary peritoneal cancer and
• Hepatocellular carcinoma

HOW BEVATAS 100MG WORKS

Bevacizumab belongs to antiangiogenic agents which works by stopping the formation of blood vessels that bring oxygen and nutrients to tumors and slows the growth and spread of tumors.

DIRECTIONS FOR USE

BEVATAS 100MG will be administered as an intravenous infusion by your doctor or nurse.

SIDE EFFECTS OF BEVATAS 100MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and drink plenty of fluids. Apply a wet or cold cloth to forehead and rest in a quiet, comfortable, dark room.

Back pain:

Use an ice pack or over the counter medicines to relieve pain.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking,

• Paclitaxel
• Carboplatin