Unclot 15 Tablet (Rivaroxaban 15mg)

INTRODUCTION

UNCLOT 15 contains rivaroxaban which belongs to the group of medicines called anticoagulants. A blood clot which blocks an artery (blood vessel) is called an embolism and if the embolism occurs in the arteries of the brain it can cause a stroke. Anticoagulants slow down the time it takes for blood to clot and reduce the risk of embolism.

This medicine is used in the treatment and prevention of deep vein thrombosis (blood clots in veins of legs) and pulmonary embolism (blood clot in lungs) in patients with or without hip or knee replacement operation. It also prevents the formation of blood clots in your brain (stroke) and other blood vessels of body among patients with non-valvular atrial fibrillation (an abnormal heartbeat).

Rivaroxaban acts by blocking the activity of blood clotting factor (factor Xa) and reduces the tendency of the blood to form clots. This medicine must be taken only with meals. The most common side effects of taking this medicine are bleeding in eyes, nose, gums, stomach, rectum or vagina. Do not take this medicine, if you have any bleeding disorders. Before taking this medicine inform your doctor if you are pregnant, breastfeeding or having any serious kidney or liver disease. This medicine is not recommended for use in children and adolescents under 18 years of age.

USES OF UNCLOT 15

Treats and prevents deep vein thrombosis
Treats and prevents pulmonary embolism in patients with or without hip or knee replacement operation
Prevents stroke and formation of blood clots in other blood vessels of body among patients with non-valvular atrial fibrillation (an abnormal heartbeat)

HOW UNCLOT 15 WORKS

Rivaroxaban reversibly inhibits both the free- and clot-bound forms of coagulation factor Xa. Inhibition of Xa, prevents the conversion of prothrombin into thrombin, which activates platelets and catalyzes the conversion of fibrinogen to fibrin thread (clot) and thus prevents blood clot formation.

DIRECTIONS FOR USE

Take this medicine as directed by your physician. It must be taken only with meals. Your doctor will decide the correct dose for you depending upon your condition. Swallow the medicine as whole with a glass of water. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

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SIDE EFFECTS OF UNCLOT 15

SERIOUS
Long or excessive bleeding
Skin reactions (such as skin rash, blisters or mucosal lesions, swelling of face, lips, mouth, tongue or throat, difficulty in swallowing or breathing, drop in blood pressure)
DRESS syndrome (fever, rash, inflammation of internal organs, hematologic abnormalities and systemic illness)
COMMON
Bleeding disorders
Bruising and swelling
Anemia, tiredness or paleness
Coughing up blood
Pain and swelling in the limbs
Fever
Stomach pain, indigestion
Nausea (feeling sick) or vomiting (being sick)
Constipation, diarrhea
Low blood pressure
Headache, dizziness
Skin rash
RARE
Bleeding into a muscle
Yellowing of skin and eye (jaundice)

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.

Constipation:

Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

WARNING & PRECAUTIONS

PREGNANCY
UNCLOT 15 is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING
UNCLOT 15 is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES
Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL
Avoid consumption of alcohol while taking this medicine.

KIDNEY
UNCLOT 15 should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.

LIVER
Do not take UNCLOT 15 if you have a liver disease which leads to increased risk of bleeding (hepatic coagulopathy). Consult your doctor for advice.

ALLERGY
Do not take this medicine if you are allergic (hypersensitive) to rivaroxaban.

LUNGS
UNCLOT 15 should be taken with caution in patients with previous bleeding from lung or bronchiectasis (bronchi are widened and filled with pus). Consult your doctor for advice.

HEART DISEASE
UNCLOT 15 should be taken with caution in patients with prosthetic heart valve. Consult your doctor for advice.

OTHERS

Inform your doctor before taking this medicine, if you have:

Any bleeding disorders

INTERACTIONS

Talk to your doctor, if you are taking,

Medicines used to treat fungal infections (e.g., ketoconazole, itraconazole, voriconazole, posaconazole)
Medicines used to treat HIV infections (e.g., ritonavir)
Medicines used to treat bacterial infection (e.g. clarithromycin, erythromycin)
Other medicines used to reduce blood clotting (e.g., enoxaparin, warfarin, rivaroxaban, dabigatran or heparin)
Medicines used to reduce pain or inflammation (e.g., acetylsalicylic acid or naproxen)
Medicines used to treat depression (e.g. fluoxetine, sertraline, imipramine, St John’s Wort)
Medicines used to treat epilepsy (e.g., phenytoin, carbamazepine, phenobarbital)
Dronedarone (used to treat abnormal heartbeat)
Rifampicin (used to treat tuberculosis)