COMMON

• Weight gain
• Sleepiness
• Pain at the site of injection
• Increases in levels of prolactin in the blood, changes in the levels of some blood cells, circulating fats and liver enzymes
• Feel dizzy (with a slow heart rate), especially while getting up from a lying or sitting position
• Increases in the level of sugars in the blood and urine and of uric acid and creatine phosphokinase in the blood
• Restlessness, tremor, unusual movements (dyskinesias)
• Constipation, dry mouth
• Rashes
• Loss of strength, extreme tiredness, feeling more hungry
• Water retention leading to swelling of the hands, ankles, or feet
• Fever, joint pain
• Sexual dysfunctions (decreased libido in males and females or erectile dysfunction in males)

UNCOMMON

• Hypersensitivity (swelling in the mouth and throat, itching, rash)
• Worsening of diabetes, at times associated with ketoacidosis (ketones in the blood, urine)
• Seizures, muscle stiffness (even eye movements)
• Syndrome of restless legs, problems with speech (stuttering)
• Sensitivity to sunlight
• Bleeding from the nose
• Abdominal distension
• Drooling
• Memory loss or forgetfulness
• Lack of ability to urinate
• Hair loss
• Absence or decrease in menstrual periods
• Changes in breasts in males and females like an abnormal production of breast milk or abnormal growth

RARE

• Lowering of normal body temperature
• Abnormal rhythms of the heart
• Inflammation of the pancreas with severe stomach pain and fever
• Liver disease (jaundice)
• Muscle disease presenting as aches and pains and painful erection

Stop receiving TOLAZ LA 405MG INJECTION and contact your doctor immediately if you experience any of the following side effects:

• Excessive sleepiness, dizziness, confusion, disorientation, difficulty talking and walking, muscle stiffness or shaking, weakness, irritability, aggression, anxiety, increase in blood pressure, or convulsions and can lead to unconsciousness
• Unusual movement of face or tongue
• Blood clots in the veins, especially in the legs (swelling, pain, and redness in the legs), which may travel through blood vessels to the lungs, causing chest pain and difficulty in breathing
• A combination of fever, faster breathing, sweating, muscle stiffness and drowsiness

PREGNANCY

TOLAZ LA 405MG INJECTION should be used with caution in pregnant women. Consult your doctor before receiving it.

BREASTFEEDING

TOLAZ LA 405MG INJECTION is not recommended for use in breastfeeding women as it can pass through breast milk. Consult your doctor before receiving it.

DRIVING AND USING MACHINES

Do not drive and use machines after receiving TOLAZ LA 405 MG INJECTION as it can make you feel drowsy.

ALCOHOL

Do not drink alcohol while receiving TOLAZ LA 405 MG INJECTION as it can make you feel drowsy.

KIDNEY

TOLAZ LA 405MG INJECTION should be used with caution in patients with kidney disease. Consult your doctor before receiving TOLAZ LA 405MG INJECTION.

LIVER

TOLAZ LA 405MG INJECTION should be used with caution in patients with liver disease. Consult your doctor before receiving TOLAZ LA 405MG INJECTION.

ALLERGY

Inform your doctor before receiving TOLAZ LA 405MG INJECTION if you are allergic to Olanzapine.

HEART DISEASE

TOLAZ LA 405MG INJECTION should be used with caution in patients with heart disease, heart attack, sick sinus syndrome (abnormal heart rhythms), unstable angina or low blood pressure. Consult your doctor before receiving TOLAZ LA 405 MG INJECTION.

OTHERS

TOLAZ LA 405MG INJECTION is not recommended for use if you:

• Have an allergic reaction such as rash, itching, a swollen face, swollen lips or shortness of breath
• Have been previously diagnosed with eye problems such as certain kinds of glaucoma (increased pressure in eye)
• Have dementia (especially in elderly patients)

Before receiving TOLAZ LA 405MG INJECTION, inform your doctor if you:

• Or your family has a history of blood clots or blood disorders
• Have stroke/mini stroke (temporary symptoms of stroke)
• Have Parkinson’s disease
• Have prostate problems
• Have blocked intestine (paralytic ileus)
• Have diabetes
• Have seizures
• May have salt depletion because of prolonged severe diarrhea and vomiting

Use in pediatrics:

TOLAZ LA 405MG INJECTION is not recommended for children and adolescents under 18 years of age. Consult your doctor before receiving TOLAZ LA 405MG INJECTION.

Use in geriatrics:

TOLAZ LA 405MG INJECTION is not recommended for elderly patients above 75 years of age, especially patients with dementia. It should be used with caution in patients above 65 years of age. Consult your doctor before receiving TOLAZ LA 405MG INJECTION.