Ticstop Tablet (Tetrabenazine 25mg)

INTRODUCTION

TICSTOP contain Tetrabenazine which belongs to a group of medicine called monoamine depletors. It is used to treat nervous system disorders and treatment of disease-causing jerky, irregular, uncontrollable movements (hyperkinetic motor disorders with Huntington’s chorea). Huntington’s disease is an inherited, rare disease that cause the progressive degeneration of nerve cells in the brain. It works by decreasing the amount of monoamines such as dopamine, serotonin, and norepinephrine. These are certain natural substances present in the brain which are involved with nerve and muscle function that helps in controlling body movements.

Always take TICSTOP exactly as your doctor has told you. This medicine must be taken with or without food. It is not recommended for use in children. Do not drive or operate machinery while taking this medicine, since it may cause drowsiness. Before taking this medicine talk to your doctor if you have any kidney, liver, heart problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine. The most common side effects are drowsiness, depression, parkinson-like syndrome (uncontrollable movements of the hand, arm, leg and head, with higher dose), confusion, anxiety, sleeplessness, trouble sleeping, low blood pressure, dysphagia (difficulty in swallowing), nausea, vomiting, diarrhoea and constipation.

USES OF TICSTOP

Treat Huntington’s chorea

HOW TICSTOP WORKS

TICSTOP works by decreasing the amount of monoamines such as dopamine, serotonin, and norepinephrine. These are certain natural substances present in the brain which are involved with nerve and muscle function that helps in controlling body movements.

DIRECTIONS FOR USE

Always take TICSTOP exactly as your doctor has told you. This medicine must be taken with or without food. Try to take this medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.

SIDE EFFECTS OF TICSTOP

SERIOUS
Suicidal thoughts or actions
Neuroleptic malignant syndrome (symptoms such as high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, increased sweating)
Dizziness due to blood pressure change when you change position (orthostatic hypotension)
Tardive dyskinesia
COMMON
Drowsiness
Depression
Parkinson-like syndrome (uncontrollable movements of the hand, arm, leg and head, with higher dose)
Confusion, anxiety
Sleeplessness, trouble sleeping
Low blood pressure
Dysphagia (difficulty in swallowing)
Nausea, vomiting
Diarrhoea
Constipation
Autonomic dysfunction (sweating and fluctuation in blood pressure)
Tiredness
Restlessness, agitation

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.

Diarrhoea:

Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without speaking to a doctor.

Constipation:

Eat fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

WARNING & PRECAUTIONS

PREGNANCY
TICSTOP is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING
TICSTOP is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES
Do not drive or operate machinery while taking this medicine, since it may cause drowsiness.

ALCOHOL
Consumption of alcohol is not recommended during treatment with TICSTOP.

KIDNEY
TICSTOP not recommended in patients with active kidney diseases. Before taking, this medicine. Consult your doctor for advice.

LIVER
TICSTOP should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.

ALLERGY
Do not take TICSTOP if you are allergic (hypersensitive) to tetrabenazine or any other ingredients in this medicine.

HEART DISEASE
TICSTOP should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.

OTHERS

Tell your doctor if you have or had a condition such as,

Suffer from parkinson-like symptoms
Depression, suicidal thoughts
Suffer from pheochromocytoma (tumour of the adrenal gland)
Suffer from pro-lactin-dependent tumours (e.g. pituitary or breast cancer)

INTERACTIONS

Talk to your doctor if you are taking,

Reserpine (used to control high blood pressure and treat psychotic states)
MAO inhibitors (used to treat depression)
Levodopa (used to treat parkinson’s disease)
Certain types of antidepressants, opioids, beta-blockers, antihypertensive drug (used to treat high blood pressure)
Hypnotics and neuroleptics (used to treat psychotic disorders)
Fluoxetine, paroxetine, terbinafine, moclobemide and quinidine
Antibiotic such as gatifloxacin, moxifloxacin (used to treat infection)
Quinidine, procainamide, amiodarone, sotalol (used to treat heart rhythm problems)