Talimus Ointment (Tacrolimus 0.1%)

About Talimus Ointment 5 gm

Talimus Ointment 5 gm belongs to a class of drugs called ‘immunosuppressants‘ used to treat moderate to severe atopic dermatitis (eczema) and prevent organ rejection after a transplant. Atopic dermatitis, also known as eczema is a common skin condition associated with inflamed and itchy skin patches. The symptoms include itchy, dry, flaky, swollen, rough and irritated skin. Organ rejection occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Talimus Ointment 5 gm contains ‘Tacrolimus‘ that works by suppressing the over-reaction of immune cells in the skin to a stimulus. Thereby, reduces allergic reaction and inflammation (redness and swelling). Also, Talimus Ointment 5 gm suppresses T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. Thereby prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

Use Talimus Ointment 5 gm as prescribed by your doctor. You are advised to use Talimus Ointment 5 gm for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience itching, burning sensation, redness, pain, skin tingling, nausea, diarrhoea, headache, increased blood sugar levels, kidney problems, dizziness or stomach pain. Most of these side effects of Talimus Ointment 5 gm do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Talimus Ointment 5 gm or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Talimus Ointment 5 gm. Avoid alcohol consumption with Talimus Ointment 5 gm as it may increase the risk of severe adverse effects. Drive only if you are alert as Talimus Ointment 5 gm may cause drowsiness, dizziness or vision problems. Do not cover or wrap the treated area with bandage or dressing.  Avoid smoking or going near naked flames as the fabric (bedding, clothing, dressings) in contact with Talimus Ointment 5 gm catches fire and burns easily.

Uses of Talimus Ointment 5 gm

Atopic dermatitis (eczema), Organ transplant

Medicinal Benefits

Talimus Ointment 5 gm contains Tacrolimus, an immunosuppressant used to treat moderate to severe atopic dermatitis (eczema) and prevent organ rejection after a transplant.  Talimus Ointment 5 gm suppresses the over-reaction of immune cells in the skin to a stimulus. Thereby, reduces allergic reaction and inflammation (redness and swelling). Also, Talimus Ointment 5 gm suppresses T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. Thereby prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

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Directions for Use

Wash your hands before and after applying Talimus Ointment 5 gm. The topical form of Talimus Ointment 5 gm can be applied as a thin layer on the clean and dry affected area of the skin as prescribed by your doctor. Talimus Ointment 5 gm is only for external use. Please avoid contact with eyes, nose or mouth as it may irritate. In case Talimus Ointment 5 gm comes in contact with these areas accidentally, rinse with water thoroughly. Take Talimus Ointment 5 gm on an empty stomach or at least 1 hour before or 2-3 hours after a meal. Talimus Ointment 5 gm in oral form can be swallowed as a whole with a glass of water. Do not break, chew or crush it. The granules form can be mixed with water just before taking. The injection form of Talimus Ointment 5 gm is given as an intravenous (into a vein) infusion by a doctor or nurse. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Talimus Ointment 5 gm

• Itching
• Burning sensation
• Redness
• Pain
• Skin tingling
• Nausea
• Diarrhoea
• Headache
• Increased blood sugar levels
• Kidney problems
• Dizziness
• Stomach pain

In-Depth Precautions and Warning

Drug Warnings

If you are allergic to Talimus Ointment 5 gm or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Talimus Ointment 5 gm. Avoid alcohol consumption with Talimus Ointment 5 gm as it may increase the risk of severe adverse effects. Drive only if you are alert as Talimus Ointment 5 gm may cause drowsiness, dizziness or vision problems. Do not cover or wrap the treated area with bandage or dressing.  Avoid smoking or going near naked flames as the fabric (bedding, clothing, dressings) in contact with Talimus Ointment 5 gm catches fire and burns easily. Please avoid contact with eyes, nose or mouth as it may irritate. Do not shower, bathe or swim immediately after applying Talimus Ointment 5 gm as it may wash off Talimus Ointment 5 gm. In case Talimus Ointment 5 gm comes in contact with these areas accidentally, rinse with water thoroughly. Do not swallow Talimus Ointment 5 gm. In case of accidental swallowing, consult a doctor immediately.

Drug Interactions

Drug-Drug Interaction: Talimus Ointment 5 gm may interact with immunosuppressant (ciclosporin), antibiotics (fluconazole, itraconazole, ketoconazole, clotrimazole, voriconazole, erythromycin, clarithromycin, rifampicin), antiemetic (metoclopramide), anticonvulsants (phenytoin, phenobarbital), antacids (lansoprazole, cimetidine, omeprazole), steroid (cortisone, prednisolone, methylprednisolone), antivirals (aciclovir), pain reliever (ibuprofen), an antidepressant (nefazodone), anticancer drugs (imatinib, nilotinib), anti-HIV drugs (nelfinavir, saquinavir, ritonavir).

Drug-Food Interaction: Talimus Ointment 5 gm may interact with St. John’s Wort (a herbal supplement to treat depression) or extracts of Schisandra sphenanthera. Avoid taking grapefruit and grapefruit juice with Talimus Ointment 5 gm as it may cause serious side effects. Also, avoid consumption of alcohol with Talimus Ointment 5 gm as it may cause flushing (make face or skin feel warm and hot) and increase other adverse effects.

Drug-Disease Interaction: If you have skin tumours, weakened immune system, infected lesions, cutaneous Graft Versus Host Disease (an immune reaction of the skin in patients who had bone marrow transplant), generalised erythroderma (inflammatory scaling and redness of entire skin), Netherton’s syndrome, lamellar ichthyosis (extensive scaling of skin), diarrhoea for more than a day, stomach pain with or without symptoms such as nausea, chills, fever or vomiting, liver or heart problems, inform your doctor before taking Talimus Ointment 5 gm.