Stresnil 0.5 Tablet (Alprazolam 0.5/Melatonin 3mg)

Stresnil 0.5mg Tablet is a combination medicine which may be used for the treatment of anxiety, sleeplessness, panic disorders, like unexpected extreme fear and tension due to stress. It is recommended to start with a small dosage and increase it gradually. Do not stop taking this medicine suddenly as it may cause withdrawal symptoms like seizures, aggressive behavior, blurred vision, etc.

Major & minor side effects for Stresnil 0.5 Tablet

Changes in pattern of Speech

Unsteadiness

Loss of coordination

Drowsiness

Blurred vision

Abdominal pain

Difficult or painful urination

Headache

Chest pain

Irregular menstrual periods

 Decreased appetite

Weight loss

Double vision

Sudden sweating

Acid or sour stomach

Heartburn

Day time drowsiness

 Stomach pain

What is it prescribed for?

Anxiety

This medicine may be used in the treatment of anxiety which is characterized by feelings of tension, worried thoughts and physical changes like increased blood pressure, uneasiness, difficulty in sleeping, sweating of hands and feet, etc.

Panic disorder

This medicine may be used in the treatment of panic disorder with symptoms like sweating, breathing problem, weakness and numbness in hands.

Insomnia (Sleeplessness)

This medicine may be used in the treatment of insomnia, a sleep disorder characterized by a difficulty in falling asleep or staying asleep.

Dosage

Allergy

This medicine is not recommended for use in patients with a known allergy to alprazolam, melatonin or any other inactive ingredients present in the formulation.

CYP3A4 inhibitors

This medicine is not recommended for use in patients who are concomitantly taking CYP3A4 inhibitors such as itraconazole, ketoconazole, etc due to the increased risk of worsening of the patient’s condition.

Acute narrow-angle glaucoma

This medicine is not recommended for use in patients with acute narrow-angle glaucoma due to the increased risk of worsening of the patient’s condition.

Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

General warnings

Drug dependence

This medicine has the potential to cause drug dependence and abuse. This risk is especially higher if the medicine is used for a prolonged period of time. Patients should be monitored closely for any change in mood and behavior during treatment with this medicine. Abrupt discontinuation is not recommended since it may cause withdrawal symptoms. Withdrawal of therapy should be done gradually with close monitoring.

Use in Children

This medicine is not recommended for use in patients below 18 years of age due to the increased risk of severe adverse effects. However, your doctor may prescribe this medicine if the benefits significantly outweigh the risks. In such a case, the patient should be monitored closely for any adverse effects.

Use in Elderly

This medicine should be used with extreme caution in individuals who are 60 years old and above due to the increased risk of sedation and muscle weakness.

Liver/Kidney Disease

This medicine should be used with caution in patients with liver/kidney diseases due to the increased risk of adverse effects. Regular monitoring of liver/kidney function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Suicidal tendencies

This medicine should be used with caution due to the increased risk of suicidal tendencies. Patients should be closely monitored for any change in mood or behavior. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Other medicines

This combination medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Instructions

Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of dizziness, difficulty in concentrating, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.

Interaction with Medicine

Antihypertensives

Sodium oxybate

Pentazocine

Codeine

Cetirizine

Metoclopramide

Warfarin

Ifosfamide

Disease interactions

Seizure disorders

This medicine should be used with extreme caution in patients with seizure disorders due to the increased risk of worsening of the patient’s condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Food interactions

Consumption of grapefruit juice is not recommended while receiving this medicine due to increased risk of adverse effects.

Lab interactions

Information not available.

This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

Take this medicine with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine before completion of the course/without consulting your doctor as it may cause withdrawal symptoms.