Pbren NT 75mg/10mg Tablet (Pregabalin 75mg/Nortriptyline 10mg)

Pbren NT 75mg/10mg

Pbren NT 75mg/10mg is a combination of Nortriptyline and Pregabalin which belongs to the group of medicines called Tricyclic antidepressants and Anticonvulsants respectively. PBREN NT is indicated for the treatment of neuropathic pain. Neuropathic pain is a chronic painful nerve condition caused by damage or disease affecting the somatosensory (sense of touch) nervous system. It can be caused by injury or disease of spinal cord and/or brain, prolonged diabetes mellitus (Ex. diabetic neuropathy), infectious diseases (such as HIV infection or leprosy), chemotherapy, auto-immune disease (Ex. Guillain-Barre syndrome), post-herpetic neuralgia (a long-lasting painful condition that affects the areas around the skin and nerve fibers where shingles were present), fibromyalgia (generalized musculoskeletal pain with fatigue, and altered sleep, memory, and mood) or by other metabolic dysfunctions. Symptoms include shooting, burning, or stabbing pain for normal daily activities that are typically not painful, tingling and numbness or spontaneous pain (pain without stimulus).

Nortriptyline is a tricyclic antidepressant that acts by inhibiting the movement of pain signals from the brain and pregabalin is an anticonvulsant that acts by blocking the influx of calcium and various pain-causing chemicals through the damaged nerves and the brain, thus causing pain relief.

Continue to take Pbren NT 75mg/10mg as long as your doctor tells you to do so, because premature discontinuation can cause withdrawal symptoms like insomnia, headache, nausea, anxiety, diarrhea, depression, convulsion, and excessive perspiration. PBREN NT can increase the risk of suicidal thoughts and behavior in some individuals and therefore, patients (or caregivers) should seek immediate medical advice if any such signs emerge.

Pbren NT 75mg/10mg is not recommended for use in patients having severe heart or kidney disease. Consult your doctor before taking PBREN NT. This medicine is not recommended for use in pregnant or breastfeeding women and in children (aged below 6 years). The most common side effects of PBREN NT are nausea, vomiting, constipation, dizziness, headache, or somnolence. Consult your doctor if any of the symptoms worsen.

USES OF Pbren NT 75mg/10mg

• Treats neuropathic pain

HOW PBREN NT WORKS

Pbren NT 75mg/10mg effectively relieves nerve pain, where nortriptyline acts by inhibiting the movement of pain signals from the brain by blocking the reuptake of certain chemical messengers (norepinephrine and serotonin) at the pre-synapse, and pregabalin acts by interfering with influx of calcium and various pain signals travelling through the damaged nerves and the brain, thus leading to a significant pain relief in various neuropathic pain states.

DIRECTIONS FOR USE

Take Pbren NT 75mg/10mg as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Do not stop taking PBREN NT without informing your doctor.

SIDE EFFECTS OF Pbren NT 75mg/10mg

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Try to take Pbren NT 75mg/10mg with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom did not improve.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.

Headache:  

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Flatulence:

Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. Consult your doctor if the symptom did not improve.

Constipation:

Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.

WARNING & PRECAUTIONS

INTERACTIONS Pbren NT 75mg/10mg

A. Drug-Drug interactions:

Before taking Pbren NT 75mg/10mg inform to your doctor, if you are taking any of these medicines:

• Other antidepressants (used to treat depression) Ex. fluoxetine, sertraline, amitriptyline, imipramine
• Antipsychotics (used to treat mental illness) Ex. chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, thioridazine
• Sympathomimetic agents (used to treat respiratory or circulatory disorders) Ex. ephedrine, adrenaline, noradrenaline, isoprenaline, phenylephrine and phenylpropanolamine
• Medicines used to treat high blood pressure (Ex. guanethidine, betanidine, debrisoquine, clonidine, reserpine)
• Medicines used to treat irregular heartbeat (Ex. quinidine, propafenone, flecainide and encainide)
• Carbamazepine (a medicine used to treat epilepsy)
• Valproic acid (used to treat epilepsy or bipolar disorder)
• Medicines used to reduce anxiety such as barbiturates (Ex. phenobarbital, pentobarbital) or lorazepam
• Cimetidine (used to treat stomach ulcers)
• Oxycodone (used to treat pain)

Overdosage:

If you or anyone else take too much of Pbren NT 75mg/10mg, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of PBREN NT include somnolence, restlessness, confusion, dizziness, change in body temperature, vomiting, blurred vision, abnormal heart rate, seizures, dry mouth, or breathing difficulties.