Pantop Injection (Pantoprazole 40mg)

INTRODUCTION

PANTOP 40MG contains Pantoprazole which belongs to the group of medicines called proton pump inhibitors. It is used to treat reflux oesophagitis (inflammation of oesophagus with regurgitation of stomach acid), stomach and duodenal ulcers, Zollinger-Ellison-Syndrome and other conditions where, too much acid are produced in the stomach. It reduces the amount of acid produced in your stomach and will only be given to you if your doctor thinks that it is more suitable for you than pantoprazole tablets at the moment.

Pantoprazole decreases stomach acid production by inhibiting the proton pump (H+ K+ ATPase). Along with this treatment, your doctor might recommend you, to take enough rest and drink plenty of fluids. Sticking to simple meals and avoiding rich or spicy food can also be beneficial. Avoid smoking and consumption of alcohol during this therapy, as it may reduce the chances of healing and worsen the ulcers.

Always take this medicine as directed by your physician, because long-term use of pantoprazole may reduce your blood magnesium levels, affect liver function or increase the risk of bone fracture. To avoid this, regular monitoring of bone functions, liver enzymes and blood magnesium levels are required during the course of treatment.The most common side effects of this medicine are vomiting, stomach pain and diarrhea. Contact your doctor if any of these symptoms bothers you. Before taking this medicine, inform your doctor if you have any liver disease. If you are pregnant or breast-feeding, consult your doctor for advice before taking this medicine. This medicine is strictly not recommended for use in children and adolescents under 18 years of age. Consult your doctor before taking.

USES OF PANTOP 40MG

Treats reflux oesophagitis
Treat stomach and duodenal ulcers
Treats Zollinger-Ellison-Syndrome

HOW PANTOP 40MG WORKS

Pantoprazole binds to and irreversibly inhibits the enzyme called H+ K+ ATPase (proton pump) in the parietal cells of the stomach, which decreases gastric acid secretions and can reduce the symptoms associated with pain and inflammation of stomach wall.

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DIRECTIONS FOR USE

This medicine will be given to you only a doctor or a nurse into a vein (intravenous infusion). Your doctor will decide the correct dose and duration for you depending upon your age, weight and health condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF PANTOP 40MG

SERIOUS
Serious allergic reactions (such as skin rash, swelling of tongue and/or throat, difficulty in swallowing, hives (nettle rash), difficulties in breathing, allergic facial swelling, severe dizziness, fast heartbeat, heavy sweating)
Signs of liver or kidney damage (yellowing of skin or whites of eyes, fever, rash, painful urination, and lower back pain)
COMMON
Thrombophlebitis (inflammation of the wall of the vein and blood clotting)
Benign polyps in the stomach
Vomiting (dark coffee grounds in your vomit)
Blood in your stools
Looking pale or weak
Stomach pain
Chest pain
Diarrhea
RARE
Lack of sense of taste
Blurred vision
Joint pain or muscle pain
Changes in weight
High fever
Swelling of extremities
Depression
Breast enlargement in males

HOW TO MANAGE SIDE EFFECTS

Skin rash:

Avoid hot showers because hot water can irritate the skin. Do not rub or scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use moisturizers to soothe and hydrate the affected area. If it does not get better, speak to your doctor.

Vomiting:

Try taking this medicine with, or just after meals. Stick to simple meals. Do not eat rich or spicy food.

WARNING & PRECAUTIONS

PREGNANCY
PANTOP 40MG should be used in pregnant women only if it is clearly necessary. Consult your doctor for advice before taking this medicine.

BREASTFEEDING
PANTOP 40MG can be excreted into the breast milk and so it is not recommended for use in breastfeeding women. Consult your doctor for advice before taking.

DRIVING AND USING MACHINES
Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL
Avoid consumption of alcohol while taking this medicine.

LIVER
PANTOP 40MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice before taking.

ALLERGY
Do not take this medicine if you are allergic (hypersensitive) to Pantoprazole or any other similar proton pump inhibitors.

OTHERS

Before taking this medicine, inform your doctor if you:

Have gastric malignancy
Are going to have any specific blood test (Chromogranin A)

INTERACTIONS

Talk to your doctor, if you are taking,

Medicines used to treat fungal infections (e.g. ketoconazole, itraconazole and posaconazole)
Medicines used to thin your blood (e.g. warfarin and phenprocoumon)
Medicines used to treat HIV-infection (e.g. atazanavir)
Corticosteroids (used to treat inflammation or allergies) e.g. prednisone, dexamethasone, beclomethasone
Erlotinib (used to treat cancer)
Methotrexate (used to treat cancer, psoriasis or rheumatoid arthritis)
Fluvoxamine (used to treat depression and other psychiatric illness)
Rifampicin (used to treat tuberculosis infection)
St John’s wort (used to treat depression)