Met XL-T 25 Tablet (Telmisartan 40mg / Metoprolol Succinate 25mg)

Medical Description

Met Xl T 40/25mg Tablet 10’S contains a combination of two medicines for hypertension – Metoprolol and Telmisartan.

Uses of Met Xl T 40/25mg Tablet 10’S

Treatment of high blood pressure.

Contraindications of Met Xl T 40/25mg Tablet 10’S

If you have any allergic reaction to this medicine or any of the ingredient of this medicine
If you are suffering from heart problems like heart block, heart failure or sick sinus syndrome (abnormal heart rhythms)
If you have a specific type of angina called Prinzmetal’s angina
If you have reduced blood supply to your limbs (peripheral arterial disease)
If you have asthma or chronic obstructive pulmonary disease (COPD)
If you are suffering from adrenal gland tumor (phaeochromocytoma)
If you have a condition called metabolic acidosis (increased acidity in your body or are on medicines to treat irregular heart rhythm like disopyramide)
If you have diabetes associated with frequent low blood sugar levels
If you are suffering from low blood pressure (hypotension)
If you are in the second or third trimester of pregnancy
If you have blockage of any duct that carries bile from the liver to gallbladder (obstructive biliary disorders) or severe liver disease
If you have diabetes and you are on Aliskiren, do not take this medicine

Side effects of Met Xl T 40/25mg Tablet 10’S

Low blood pressure or giddiness when you stand
Tiredness
Slow heart rate
Dizziness
Headache
Nausea or vomiting
Stomach pain
Shortness of breath
Flu-like symptoms
Diarrhoea
Conjunctivitis (inflammation of eye also known as pink eye)
Palpitations (irregular heartbeats)
Constipation
Chest pain
Dry Mouth
Flatulence
Joint pain
Muscle spasm or pain
Anxiety
Skin disorders like rash

Other General Warnings

Talk to your doctor if
If you have asthma
If you have diabetes, caution is required. Metoprolol may cause low blood sugar levels and also change the body’s response to low blood sugar. You may experience warning signs of low blood sugar such …
If you have a tumour of adrenal gland tissue (Pheochromocytoma)
If you have an overactive thyroid (a condition when the thyroid gland produces too much of the thyroxine hormone)
If you are suffering from psoriasis
If you have a circulation related problem in toes, arm, legs or fingers
If you are suffering from a type of chest pain (Prinzmetal’s angina)
If you recently had any heart attack, chest pain or heart surgery
If you have kidney disease or have had a kidney transplant or liver disease
If you are known to have narrowed or blockage of the blood vessels of one or both kidneys
If you develop diarrhoea or vomiting, this dehydration can result in low blood pressure, have an adequate amount of water and fluids
If you are suffering from low blood pressure (hypotension)
If you have a high level of potassium in your blood
If you are taking medicines like Ramipril and Lisinopril

Mode of Action of Met Xl T 40/25mg Tablet 10’S

How Does It Work?
Metoprolol works by slowing the heart rate and relaxing blood vessels and reduces high blood pressure
Angiotensin II is a substance produced in the body which causes the narrowing of blood vessels. It leads to an increase in blood pressure
Telmisartan prevents the binding of Angiotensin II to its receptors and causes the blood vessels to relax and lowers the blood pressure

Directions for Use of Met Xl T 40/25mg Tablet 10’S

Take Met Xl T 40/25mg Tablet 10’S as directed by your doctor
Always take it at the same time every day
Never change the dose or stop this medicine on your own

Interactions of Met Xl T 40/25mg Tablet 10’S

Interactions with other medicines
This medicine contains Metoprolol and Telmisartan, any interactions seen with these two components when taken alone may occur with this combination
Do not take it with medicines like Amiodarone, Disopyramide or painkillers like Indomethacin, Sulindac, Diclofenac and Foctafenine as these can decrease the effect of this medicine
If you have diabetes, dose adjustment may be needed as this medicine can cause a drop in blood glucose levels and close glucose monitoring is advised
Medicines used to treat high blood pressure and benign prostatic hyperplasia (Prazosine, Tamsulosin, Terazosin and Doxazosin)
If you have diabetes and you are on Aliskiren, do not take this medicine
Caution is needed if you are taking Fluoxetine, Lithium, Paroxetine, Bupropion, Thioridazine (medicines for psychiatric illness), Diphenhydramine, Hydroxychloroquine and Mefloquine
Medicines used to treat acidity or ulcers (antacids) like Cimetidine
Medicines used to treat heart problems (Digoxin)
Medicines used to treat depression and Parkinson’s disease (Monoamine Oxidase inhibitors)
Medicines used to lower down the blood pressure (Clonidine, Guanfacine, Moxonidine, Methyldopa and Rilmenidine)
Medicines used to treat migraine (Ergotamine) or Nitroglycerine
General anaesthetics or local anesthetic (Lidocaine)
Medicines that may increase blood potassium levels like salt containing potassium and potassium-sparing diuretics
Blood thinners like Warfarin and Heparin
Immunosuppressives (Cyclosporin or Tacrolimus)
Medicines used to treat infections like Trimethoprim, Rifampicin or Terbinafine
Medicines known as Diuretics (water pills) used to treat high blood pressure like Furosemide and Hydrochlorothiazide
Interactions with food items
It is advised to avoid high potassium-containing foods like spinach, broccoli and potatoes as Telmisartan is known to increase blood potassium levels.

Storage and disposal of Met Xl T 40/25mg Tablet 10’S

Store below 25°C
Store it in original packing to protect it from light
Try to keep out of the reach of children

Dosage of Met Xl T 40/25mg Tablet 10’S

Overdose
Symptoms of overdose may include low blood pressure, irregular heartbeat, heart failure, shock, loss of consciousness, coma, nausea, vomiting, bluish colour of the lips, tongue and skin, low levels of potassium or calcium in blood, dizziness and kidney failure. In case of an overdose, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
If you missed a dose of this medicine, take it as soon as you remember. If it’s time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose of this medicine to compensate for the missed one.