Macox Plus 450mg (Rifampicin 450mg / Isoniazid 300mg)

Macox Plus 450mg

Macox Plus 450mg is a type of anti-tubercular drug which is used in the treatment of tuberculosis. Tuberculosis is an infectious disease that affects the lungs caused by a bacteria, namely Mycobacterium tuberculosis. Macox Plus is a combination of two drugs, namely Rifampicin and Isoniazid. It works by stopping the growth of bacteria responsible for causing tuberculosis.

Uses of Macox Plus 450/300mg Tablet

Specifically used for the treatment of tuberculosis.

Contraindications of Macox Plus 450/300mg Tablet

If you are allergic to Macox Plus or any of its ingredients. If you are taking antiviral medicines. If you have any type of liver disease/damage. If you have a visual disorder. If you have had diabetes If you have epilepsy, gout. If you have HIV (Human Immunodeficiency Virus) If you have mental health issues or any other disease. If you are pregnant, lactating or want to conceive.

Side effects of Macox Plus 450/300mg Tablet

Nausea
Vomiting
Drowsiness
Dizziness
Headache
Numbness/ Tingling sensation
Diarrhoea
Heartburn
Easy Bruising/Bleeding
Can change the colour of urine, sweat, or saliva to dark yellow.

Other General Warnings

Talk to your doctor if
If you have to start with any vitamins or supplements along with the medication, even if the supplement is herbal, ayurvedic or any other category.
You experience vision issues, allergic reactions or joint pain after taking the medication.
Macox Plus tends to decrease the effectiveness of hormonal birth control, so one should adopt additional methods of contraception to ensure safety.
Not recommended for children below 15 years of age.
Seek immediate help if you notice any severe side effects or worsening of other side effects.
Do not stop taking the dose on your own if you start feeling better without consulting your doctor. It can worsen the situation.

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Mode of Action of Macox Plus 450/300mg Tablet

How Does It Work?
Macox Plus contains two active ingredients: Rifampicin (450 mg) and Isoniazid(300 mg). Rifampicin works by inhibiting a bacterial enzyme that helps grow bacteria. Isoniazid works on the cell wall of bacteria and thereby deactivating the bacteria. Both of these work together against the growth of bacteria.

Directions for Use of Macox Plus 450/300mg Tablet

Macox Plus should be taken according to the recommendation of a doctor.
It is usually taken as a long term medicine in combination with other medicines.
It has to be taken on an empty stomach, preferably 1 hr before taking food or 2 hrs after the food. Try to maintain a schedule and have the medicine at the same time every day.
The tablet has to be swallowed whole orally with a glass of water. The tablet should not be chewed, crushed or broken.

Interactions of Macox Plus 450/300mg Tablet

Interactions with other medicines
Antiviral medicines
Antidepressant
MAO inhibitors
Blood thinners
Acetaminophen
Diltiazem
Ethambutol
Interactions with food items
Alcohol
Avoid consuming alcohol while taking Macox Plus. It can increase the risk of liver damage; hence you should avoid it.
Food
Avoid tyramine/histamine containing cheese, red wine, fish, soy, tuna, salmon, beer.

Storage and disposal of Macox Plus 450/300mg Tablet

Store the medicine at room temperature away from any source of direct heat. Try to avoid keeping the medicine in direct sunlight. The medicine does not need to be refrigerated. Keep it away from the reach of children as well as any pets.

Dosage of Macox Plus 450/300mg Tablet

Overdose
Do not take medicine more than the advised dosage. In case of an allergic reaction like swelling of the face or tongue, rush to the hospital. Overdose can exhibit severe side effects. Seek immediate help in case of overdose.
Missed a Dose
If you miss a dose, try to take the tablet as soon as you remember. If it is almost the time of the next dose, do not take the double dose. Try to stick to the previous schedule. Consider setting the alarm if you keep forgetting to take the medication. It is of utmost importance to be regular with this medicine.