Macox-ZH Tablet (Isoniazid 150mg / Pyrazinamide 750mg / Rifampicin 225mg)

Macox-ZH Tablet

Macox-ZH Tablet is a combination medicine which may be used for the treatment of tuberculosis. It is important to continue treatment with this medicine even if you feel better; do not stop the use of this medicine without consulting your doctor.

Side effects

Major & minor side effects for Macox ZH Tablet
Abdominal pain
Dizziness
Headache
Yellow colored eyes or skin
Skin rash
Muscle pain
Dark urine
Loss of appetite
Nausea or vomiting
Unusual tiredness or weakness
Tingling or numbness of the hands and feet
Depression
Joint pain
Unusual bleeding or bruising

Uses of Macox ZH Tablet

What is it prescribed for?
Tuberculosis
This medicine is used in the treatment of active tuberculosis, a type of lung infection caused by Mycobacterium tuberculosis.

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When not to use?

Allergy
This medicine is not recommended for use in patients with a known allergy to isoniazid, rifampicin, pyrazinamide, or any other inactive ingredients present in the formulation.
Antiviral medications
Macox-ZH medicine is not recommended for use in patients receiving antiviral therapy since it may reduce the effects of antiviral medications and may lead to the development of viral resistance.
Severe Hepatic impairment
This medicine is not recommended for use in patients suffering from a severe hepatic impairment or an acute liver disease due to the increased risk of worsening of the patient’s condition.
Acute Gout
This medicine is not recommended for use in patients with increased uric acid levels or acute gout due to the increased risk of worsening of the patient’s condition.

Warnings

Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings
Liver Disease
This medicine should be used with extreme caution in patients with a known history of liver diseases due to the increased risk of worsening of the patient’s condition. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.
Diabetes
This medicine should be used with caution in patients with a history of diabetes since it may alter the blood glucose levels. Close monitoring of blood glucose levels, appropriate patient education, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.
Drug-resistance
Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug-resistant.
Kidney Disease
This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.
Liver enzymes
Use of this medicine may elevate liver enzyme levels in some patients. Close monitoring of liver enzyme levels, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.
Skin Reactions
Use of this medicine may cause severe skin reactions including Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in some patients. Report any skin rashes or mucosal lesions to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.
Driving or Operating machinery
Use of this medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Dosage

Missed Dose
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.

General Instructions

Take this medicine on an empty stomach, either 1 hour before or 2 hours after a meal. The absorption of this medicine may be reduced if it is taken along with food. Do not consume in larger or smaller amounts than advised. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.