Espin 1.25mg Tablet (Amlodipine 2.5mg / Hydrochlorothiazide 12.5mg)

INTRODUCTION

ESPIN contains Amlodipine which belongs to a group of medicines called calcium antagonists. It is used to treat high blood pressure (hypertension), chest pain due to narrowing of the blood vessels of the heart muscle (angina pectoris) or a rare form of chest pain due to cramping of the blood vessels of the heart muscle (prinzmetal or variant angina). It can be used alone or in combination with other medicines to treat these conditions.

High blood pressure usually occurs from blood pushing too hard against your blood vessels. Pain or discomfort that keeps coming back when part of your heart does not get enough blood is defined as angina.

Always take this medicine exactly as your doctor has directed you. It should be taken with a glass of water with or without food. Drinking grapefruit juice and taking grapefruit should be avoided while taking this medicine. Before taking it, tell your doctor know if you have any liver, heart, or kidney problems. Inform your doctor what other medicines you are taking, especially those used to treat high blood pressure or heart conditions. This medicine is not recommended for use in children aged under 6 years.

USES OF ESPIN

High blood pressure (hypertension)
Angina

HOW ESPIN WORKS

High blood pressure: This medicine reduces blood pressure by relaxing blood vessels, so that blood passes through them more easily
Angina: This medicine improves blood supply to the heart muscle which then receives more oxygen and as a result chest pain is prevented

DIRECTIONS FOR USE

Always take this medicine exactly as your doctor has directed you. It should be taken with a glass of water with or without food. Drinking grapefruit juice and taking grapefruit should be avoided while taking this medicine.

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SIDE EFFECTS OF ESPIN

SERIOUS
Chest pain followed by shortness of breath or difficulty in breathing
Swelling of eyelids, face or lips
Skin rash, hives, reddening of the skin
Inflamed pancreas
COMMON
Oedema (fluid retention)
Headache, dizziness
Sleepiness
Palpitations
Abdominal pain
Feeling sick (nausea)
Altered bowel habits
Diarrhoea
Constipation
Tiredness or weakness
Visual disturbances, double vision
Muscle cramps
Swollen ankles
RARE
Confusion

HOW TO MANAGE SIDE EFFECTS

Feeling sick (nausea) or indigestion:

Have simple meals and avoid eating rich or spicy foods.

Drowsiness or dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

Diarrhoea:

Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.

Constipation:

Add fruits, vegetables whole grains and other high-fiber foods to your diet.

INTERACTIONS

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:

Any other hypertensives
Verapamil, diltiazem
Ketoconazole and itraconazole (used to treat fungal infections)
Ritonavir
Clarithromycin, erythromycin and telithromycin, rifampicin, rifabutin (antibiotics)
Nefazodone (used to treat depression)
Dexamethasone (used to treat inflammatory and autoimmune conditions)
Dantrolene
Simvastatin (cholesterol lowering medicine)
Cyclosporine, tacrolimus (immunosuppressant)
Phenobarbital, phenytoin and carbamazepine (used for epilepsy)
Sildenafil (used for impotence)