Zoryl-M4 Tablet (Glimepiride 4mg / Metformin 500mg)

INTRODUCTION

ZORYL M4 FORTE is a combination of Glimepiride and Metformin which belongs to a group of medicines called Antidiabetic agents. ZORYL M4 FORTE is used to treat type 2 diabetes mellitus when diet, exercise and the single agent does not result in adequate glycemic control. Type 2 diabetes is a chronic medical condition in which the body does not make enough insulin, or the produced insulin does not work well. Symptoms include excessive urination, excessive thirst, hunger, fatigue, and blurred vision.

Glimepiride lowers blood sugar by causing the pancreas to produce more insulin and helps the body use insulin efficiently. Metformin is a biguanide which effectively reduces the total amount of sugar released into the blood by the liver. Along treatment with ZORYL M4 FORTE follow regular exercise and diet plan as advised by your doctor to achieve better results.

Before taking ZORYL M4 FORTE inform your doctor if you have type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney disease, acute heart problems. Inform your doctor if you are pregnant or breastfeeding. It is not suitable for use in children and adolescents under 18 years of age. Avoid consumption of alcohol during treatment with ZORYL M4 FORTE as it may increase or decrease the blood sugar lowering action of ZORYL M4 FORTE and increases the risk of lactic acidosis. The most common side effects of taking ZORYL M4 FORTE are taste disturbance, nausea, diarrhea, stomachache, and vomiting. Contact your doctor if any of the symptoms worsen.

USES OF ZORYL M4 FORTE

• Treats type 2 diabetes mellitus (when diet, exercise and the single agent does not result in adequate glycemic control)

HOW ZORYL M4 FORTE WORKS

ZORYL M4 FORTE controls blood glucose levels, where glimepiride works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin works by lowering glucose production in the liver, delaying glucose absorption from intestine, and increasing the body’s sensitivity to insulin.

DIRECTIONS FOR USE

Take ZORYL M4 FORTE as advised by your physician. Swallow ZORYL M4 FORTE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking ZORYL M4 FORTE without informing your doctor.

SIDE EFFECTS OF ZORYL M4 FORTE

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Consult your doctor if the symptom did not improve.

Loss of appetite:

Eat when you feel hungry. Eat smaller meals frequently than usual. Snack only when you’re hungry. Consult your doctor if the symptom did not improve.

Nausea and vomiting:

Stick to simple meals. Avoid eating oily, fried, and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking ZORYL M4 FORTE inform to your doctor, if you are taking any of these medicines:

• Other sulphonylureas such as glibenclamide, insulin (used to lower blood sugar levels)
• Anabolics (supports muscle build up)
• Warfarin (treats blood clot)
• Fenfluramine (used to reduce weight)
• Phenylbutazone, azopropazone, oxyphenbutazone (treats pain and inflammation)
• Disopyramide (treats heart problems)
• Fibrates such as fenofibrate, nicotinic acid, colesevelam (lowers high cholesterol level)
• Angiotensin-converting enzyme (ACE) inhibitors such as captopril, lisinopril, diuretics such as furosemide, chlorthalidone, hydrochlorothiazide or diazoxide (treats blood pressure)
• Fluoxetine, monoamine oxidase inhibitors such as isocarboxazid, selegiline and chlorpromazine (used to treat mental disorders)
• Allopurinol, probenecid, sulfinpyrazone (treats gout)
• Cyclophosphamide, ifosfamide, trofosfamide (treats cancer)
• Tetracyclines (Ex. minocycline, doxycycline), chloramphenicol, fluconazole, miconazole, quinolones (Ex. moxifloxacin, ciprofloxacin), clarithromycin, rifampicin (treats bacterial and fungal infections)
• Tritoqualine, glucocorticoids (Ex. beclomethasone, hydrocortisone) (treats nasal allergies)
• Pentoxifylline in high doses of intravenous infusion (used to improve blood flow)
• Sulfonamides such as sulfamethoxazole (treats urinary infections)
• Medicines used for male sex hormone replacement therapy (Ex. testosterone) and medicines containing female sex hormones (Ex. oestrogens, progestogens)
• Sympatholytics such as clonidine, methyldopa (treats high blood pressure, heart failure, or prostate symptoms)
• Levothyroxine (used to stimulate thyroid gland)
• Adrenaline and sympathomimetics such as phenylephrine, norepinephrine (treats life-threatening cardiac arrest and low blood pressure)
• Laxatives such as bisacodyl (treats constipation)
• Phenytoin (treats fits)
• Glucagon (used to treat severely low blood sugar)
• Barbiturates such as pentobarbital, amobarbital (treats nervousness and sleep problems)
• Acetazolamide (treats increased pressure in the eye)

Overdosage:

If you or anyone else take too much of ZORYL M4 FORTE, contact your doctor immediately or go to a nearest hospital straight away. Overdosage symptoms of ZORYL M4 FORTE includes risk of low blood sugar levels (in severe cases it may lead to loss of consciousness and coma) and it may cause life-threatening lactic acidosis. Symptoms of lactic acidosis include vomiting, bellyache with muscle cramps, general feeling of not being well with severe tiredness, reduced body temperature, low heartbeat, and difficulty in breathing.