Lefumide 20 Tablet (Leflunomide 20mg)

Lefumide 20 Tablet

Lefumide 20Mg Tablet is an immunosuppressive disease-modifying antirheumatic drug. It is a pyrimidine synthesis inhibitor. It is used to treat rheumatoid arthritis. It functions by reducing joint pain and swelling.

Certain side-effects that you may experience on using Lefumide 20Mg Tablet are dizziness, nausea, diarrhoea, hair loss, headache, respiratory tract infections, cough, difficulty breathing, stomatitis, fatigue, itchiness and pharyngitis. Should your allergic reactions continue or worsen over time, immediately contact your health care provider.

Before using Lefumide 20Mg Tablet have a word with your doctor and inform him/her if: you are allergic to any medication, food, substance or any ingredient contained within Lefumide 20Mg Tablet, you are pregnant, or are planning to become pregnant or are nursing a baby, you have a weak immune system, you have liver, lung or kidney problems and if you are taking any prescription or non-prescription drugs.

The dosage should be ideally prescribed by your doctor. This medication comes in a tablet form. Usually the adult dose for Lefumide 20Mg Tablet is about 20 mg (maintenance dose) to be taken through the mouth once for over a period of 3 days.

If diabetic, monitor blood sugars closely; this medication may alter glucose levels. There is no human experience with overdosage. Lefumide 20Mg Tablet is not dialyzable. Cholestyramine and/or activated charcoal enhance elimination of leflunomide’s active metabolite (MI).

In cases of significant overdose or toxicity, cholestyramine 8 g every 8 hours for 1-3 days may be administered to enhance elimination. Plasma levels are reduced by approximately 40% in 24 hours and 49% to 65% after 48 hours of cholestyramine dosing.

Take as directed; do not increase dose without consulting prescriber. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). Store medication away from light.

Lefumide 20Mg Tablet has been associated with teratogenic and embryolethal effects in animal models at low doses. Lefumide 20Mg Tablet is contraindicated in pregnant women or women of childbearing potential who are not using reliable contraception.

Pregnancy must be excluded prior to initiating treatment. Following treatment, pregnancy should be avoided until the drug elimination procedure is completed.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Rheumatologist before using this medicine.

Use

The primary use of this medication is as follows:

Rheumatoid Arthritis

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Side Effects

Following are some of the common side effects that may occur:

Diarrhoea

Hypertension

Chest Pain

Headache

Dizziness

Pain

Fever

Migraine

Anxiety

Depression

Insomnia

Sleep Disorders

Alopecia

Rash

Dosage

Are there any missed dose instructions?

If you miss a dose of Lefumide 20Mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Work

Lefumide 20Mg Tablet is a prodrug with anti-inflammatory and immunosuppressive properties that works by breaking down into its active metabolite A77 1726 once ingested which then blocks an important enzyme for de novo pyrimidine synthesis, dihydroorotate dehydrogenase. This inhibits the growth of activated T-lymphocytes.