Glyxambi 25mg/5mg Tablet (Empagliflozin 25mg / Linagliptin 5mg)

Medical Description

Glyxambi tablet is an anti-diabetic medication, used to treat type 2 diabetes in adults. Type 2 diabetes mellitus is a condition in which your pancreas does not make enough insulin to control blood sugar levels and your body is also unable to efficiently use its own insulin. This causes high blood sugar levels in your body, which can further lead to other health consequences like heart disease, kidney disease, blindness and decreased blood flow in your hands and legs. Glyxambi tablet is a combination of two active substances- empagliflozin and linagliptin. These medicines work together to lower the raised blood sugar levels by improving insulin release. The excess sugar is excreated via urine. Take this medicine exactly as recommended by your doctor. It is important that you exercise regularly and have a balanced diet while taking Glyxambi tablets for adequate control of your blood sugar levels.

Uses of Glyxambi 25mg/5mg Tab 10’S

Glyxambi tablet is used for the treatment of Type 2 diabetes mellitus in adults.

Contraindications of Glyxambi 25mg/5mg Tab 10’S

If you are allergic to empagliflozin, linagliptin or any other ingredient of Glyxambi tablets.
If you are allergic to any other sodium-glucose-cotransporter 2/SGLT2 (dapagliflozin, canagliflozin, ertugliflozin, remogliflozin, tofogliflozin) or dipeptidyl-peptidase-4/DPP4 (sitagliptin, saxagliptin, vildagliptin, alogliptin) inhibitor.
If you are not sure what these medicines are, please confirm with your doctor.

Side effects of Glyxambi 25mg/5mg Tab 10’S

Cough
Rash
Itching
Frequent urination
Low blood sugar level
Urinary tract infection

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Other General Warnings

Talk to your doctor if
You have type 1 diabetes (where your body does not produce any insulin). This medicine should not be taken in such cases.
You have diabetic ketoacidosis (a serious complication of diabetes) or develop symptoms of diabetic ketoacidosis like rapid weight loss, nausea, vomiting, excessive thirst, difficulty in breathing, unusual sleepiness, tiredness, sweet smell to your breath, sweet or metallic taste to your mouth, or a different smell or colour of your urine.
You have a fever, diarrhoea or if you are not able to eat or drink.
You are taking any other anti-diabetic medication that belongs to the class of sulfonylurea (glyburide, glimepiride, glipizide, tolazamide, chlorpropamide) or insulin.
You have kidney disease or liver disease.
You have or had a history of disease of the pancreas.
You take medicines called diuretics or medicines that lower blood pressure. If you are not sure what these medicines are, confirm with your doctor.
You are older than 75 years of age.
You develop symptoms of acute pancreatitis, like continuous, severe stomach pain.
You have a serious infection of the kidney or the urinary tract along with fever.
You develop disorders of the skin like blisters and ulcers.
You develop symptoms of pain, tenderness, redness or swelling of the genitals or the area between the genitals and anus with fever.
You develop any kind of infection of the feet.

Mode of Action of Glyxambi 25mg/5mg Tab 10’S

How Does It Work?
Empagliflozin blocks a certain protein in the kidneys called sodium-glucose co-transporter 2 (SGLT-2) and prevents the reabsorption of glucose (sugar) by the kidneys. This causes the removal of blood sugar through the urine.
Linagliptin acts by blocking another protein called dipeptidyl-peptidase 4 (DPP-4). This causes the pancreas to produce more insulin when blood sugar levels are high, like after a meal. As a result, Glyxambi lowers your blood sugar levels and keeps them adequately controlled.

Directions for Use of Glyxambi 25mg/5mg Tab 10’S

Take this medicine as a whole with sufficient water.
Always take this medicine exactly as prescribed by your doctor.
Do not consume more than the prescribed dose.
Do not discontinue the medicine on your own without consulting your doctor.

Interactions of Glyxambi 25mg/5mg Tab 10’S

Interactions with other medicines
Some medicines can affect the way Glyxambi tablet works or Glyxambi tablet itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
Glyxambi when coadministered with insulin or sulphonylureas (glyburide, glimepiride, glipizide, tolazamide, chlorpropamide) may increase the risk of hypoglycaemia (low blood sugar levels).
Glyxambi may cause dehydration and low blood pressure when taken along with diuretics like thiazides (hydrochlorothiazide, chlorthalidone, metolazone, indapamide) and loop diuretics (furosemide, bumetanide, torasemide, ethacrynic acid).

Storage and disposal of Glyxambi 25mg/5mg Tab 10’S

Store in a cool and dry place away from direct sunlight.
Keep it out of reach of children and pets.

Dosage of Glyxambi 25mg/5mg Tab 10’S

Overdose
If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
You should never miss your blood sugar medicines as it may lead to high blood sugar and symptoms associated with it. However, if you missed any dose of the medicine, take it as soon as you remember. If it’s time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.