Glynase-MF Tablet (Glipizide 5mg / Metformin 500mg)

name belongs to the class of anti-diabetic drugs. It is used in the treatment of type 2 diabetes mellitus. Diabetes mellitus is a metabolic disease that causes high blood sugar levels.

It occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produces little or no insulin at all.

Glynase-MF Tablet 10’s is composed of two medicines, namely Glipizide and Metformin. Glipizide belongs to the class of sulfonylureas. It is used in the treatment of diabetes mellitus as an adjunct to diet and exercise. Metformin belongs to the class of biguanides and is used to manage blood sugar levels, particularly in obese patients.

Glipizide promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver. It exhibits an extra pancreatic effect by improving the insulin sensitivity at peripheral sites like muscle, fat, or liver cells. Glipizide partially blocks the potassium channels in the beta cells of the pancreas, which leads to the opening of calcium channels. This effect causes insulin secretion from the pancreatic beta cells. It has the fastest absorption and onset of action compared to other sulfonylureas. Metformin exhibits a non-pancreatic effect to reduce serum glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin. Metformin is considered to be a unique anti-diabetic drug since it does not cause hypoglycemia (lowered blood sugar levels).

Glynase-MF Tablet 10’s is an orally administered drug. Take this drug with food at regular intervals as prescribed by your doctor to avoid stomach upset. Do not crush, chew, or break the tablet. Your doctor will decide the dosage form, and this may change timely depending on your blood sugar levels. Do not stop taking this medicine on your own, since it may cause a rise in your blood sugar levels leading to other health issues like kidney damage, blindness, and loss of limbs. The common side effects of Glynase-MF Tablet 10’s include hypoglycemia (low blood sugar levels), nausea, diarrhea, indigestion, headache, dizziness, blurred vision, weakness, cold sweats, stomach pain, weight gain, and oedema (swelling). Although not everyone experiences these side effects, if they occur, seek medical attention.

Before starting Glynase-MF Tablet 10’s, let your doctor know if you have any medical history of anaemia (low hemoglobin levels), seizures (fits), heart, kidney, and liver diseases. Also, speak to your doctor if you are on restricted food or fluid intake since Glynase-MF Tablet 10’s causes dehydration, low blood sugar, and kidney damage. Do not take or stop this medicine, if the doctor did not advise you to do so.

Type 2 Diabetes mellitus

Glynase-MF Tablet 10’s is used to treat type 2 diabetes mellitus. Glipizide is effective in treating the low blood sugar levels when used as an adjunct to diet and exercise. It promotes the insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver. It also exhibits an extra pancreatic effect by improving insulin sensitivity at peripheral sites like muscle, fat, or liver cells. Metformin shows non pancreatic effect to reduce serum glucose levels without increasing the insulin secretion. It is also known as insulin sensitizer as it increases the effects of insulin. It is considered to be a unique anti-diabetic drug since it does not lower the blood sugar levels. Metformin does not cause weight gain in most cases.

Related Product

Glynase-MF Tablet 10’s is available as an oral tablet formulation. Your doctor prescribes the dosage based on your disease conditions and tolerance. Do not chew, crush or break the tablet and swallow it as a whole with a glass of water. Take Glynase-MF Tablet 10’s preferably with a meal, since it lowers the blood sugar levels and causes gastrointestinal side effects. Your doctor may start the course with a low dose and gradually maintain an effective dose to achieve the required blood glucose control.

Store in a cool and dry place away from sunlight

Most of the side effects of Glynase-MF Tablet 10’s do not require medical attention and gradually resolve over time. Glynase-MF Tablet 10’s can cause common side effects like hypoglycemia (low blood sugar levels), nausea, diarrhea, indigestion, headache, blurred vision, dizziness, weakness, cold sweats, stomach pain, weight gain, and oedema (swelling). Seek medical advice if these side effects persist longer.

Some less common side effects of Glynase-MF Tablet 10’s include anxiety, depression, chills, fast heartbeat, seizures, decreased vitamin b12 absorption, weight loss, skin rashes, slurred speech, cough, sore throat, bladder pain, frequent urge to urinate, decreased hunger, and lactic acidosis (a rare, but serious metabolic complication of excess lactic acid in the blood that is caused by metformin accumulation). The risk of lactic acidosis is high in people with kidney, liver, and heart diseases. It is essential to speak to your doctor about your medical history before you take Glynase-MF Tablet 10’s. If any of these side effects occur and persist longer, call your doctor for emergency treatment.