Atrest 12.5 Tablet (Tetrabenazine 12.5mg)

INTRODUCTION

ATREST 12.5MG contain Tetrabenazine which belongs to a group of medicine called monoamine depletors. It is used to treat nervous system disorders and treatment of disease-causing jerky, irregular, uncontrollable movements (hyperkinetic motor disorders with Huntington’s chorea). Huntington’s disease is an inherited, rare disease that cause the progressive degeneration of nerve cells in the brain. It works by decreasing the amount of monoamines such as dopamine, serotonin, and norepinephrine. These are certain natural substances present in the brain which are involved with nerve and muscle function that helps in controlling body movements.

Always take ATREST 12.5MG exactly as your doctor has told you. This medicine must be taken with or without food. It is not recommended for use in children. Do not drive or operate machinery while taking this medicine, since it may cause drowsiness. Before taking this medicine talk to your doctor if you have any kidney, liver, heart problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine. The most common side effects are drowsiness, depression, parkinson-like syndrome (uncontrollable movements of the hand, arm, leg and head, with higher dose), confusion, anxiety, sleeplessness, trouble sleeping, low blood pressure, dysphagia (difficulty in swallowing), nausea, vomiting, diarrhoea and constipation.

USES OF ATREST 12.5MG

• Treat Huntington’s chorea

HOW ATREST 12.5MG WORKS

ATREST 12.5MG works by decreasing the amount of monoamines such as dopamine, serotonin, and norepinephrine. These are certain natural substances present in the brain which are involved with nerve and muscle function that helps in controlling body movements.

DIRECTIONS FOR USE

Always take ATREST 12.5MG exactly as your doctor has told you. This medicine must be taken with or without food. Try to take this medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.

SIDE EFFECTS OF ATREST 12.5MG

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.

Diarrhoea:

Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without speaking to a doctor.

Constipation:

Eat fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor if you are taking,

• Reserpine (used to control high blood pressure and treat psychotic states)
• MAO inhibitors (used to treat depression)
• Levodopa (used to treat parkinson’s disease)
• Certain types of antidepressants, opioids, beta-blockers, antihypertensive drug (used to treat high blood pressure)
• Hypnotics and neuroleptics (used to treat psychotic disorders)
• Fluoxetine, paroxetine, terbinafine, moclobemide and quinidine
• Antibiotic such as gatifloxacin, moxifloxacin (used to treat infection)
• Quinidine, procainamide, amiodarone, sotalol (used to treat heart rhythm problems)