Apriglim-M 4 Tablet (Glimepiride 4mg / Metformin 500mg)

About Apriglim-M 4 Tablet 10’s

Apriglim-M 4 Tablet 10’s belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose. People with type 2 diabetes either do not produce enough insulin, or the insulin produced is unable to perform its function in the body (insulin resistance).

Apriglim-M 4 Tablet 10’s is a combination of two antidiabetic drugs, namely: Glimepiride and Metformin. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin PR is a prolonged-release formulation that releases the drug in smaller portions over a longer duration of time. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood.

Take Apriglim-M 4 Tablet 10’s as prescribed by your doctor. You are advised to take Apriglim-M 4 Tablet 10’s for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects of Apriglim-M 4 Tablet 10’s do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Apriglim-M 4 Tablet 10’s or any other medicines, please tell your doctor. Apriglim-M 4 Tablet 10’s is not recommended for children. Avoid breastfeeding while taking Apriglim-M 4 Tablet 10’s as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking Apriglim-M 4 Tablet 10’s as it may harm the unborn baby. Avoid alcohol consumption with Apriglim-M 4 Tablet 10’s as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking Apriglim-M 4 Tablet 10’s. Take short, frequent meals and avoid prolonged fasting while taking Apriglim-M 4 Tablet 10’s.

Uses of Apriglim-M 4 Tablet 10’s

Type 2 diabetes mellitus

Medicinal Benefits

Apriglim-M 4 Tablet 10’s contains Glimepiride and Metformin used in the treatment of type 2 diabetes. Glimepiride stimulates cells in the pancreas that produce insulin which helps to remove sugar from the blood. Metformin PR is a prolonged-release formulation that releases the drug in smaller portions over a longer duration of time. Metformin reduces the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood.

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Directions for Use

Tablet: Swallow the tablet as a whole with a glass of water. Do not crush or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Apriglim-M 4 Tablet 10’s

• Stomach pain
• Nausea
• Diarrhoea
• Vomiting
• Headache
• Metallic taste

In-Depth Precautions and Warning

Drug Warnings

If you are allergic to Apriglim-M 4 Tablet 10’s or any other medicines, please tell your doctor. Apriglim-M 4 Tablet 10’s is not recommended for children. Avoid breastfeeding while taking Apriglim-M 4 Tablet 10’s as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking Apriglim-M 4 Tablet 10’s as it may harm the unborn baby. Avoid alcohol consumption with Apriglim-M 4 Tablet 10’s as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking Apriglim-M 4 Tablet 10’s. Take short, frequent meals and avoid prolonged fasting while taking Apriglim-M 4 Tablet 10’s. Beware of symptoms of hypoglycaemia (low blood sugar) which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination etc. Whenever you experience any of these symptoms, immediately consume 5-6 candies or 3 glucose biscuits or 3 teaspoons of honey/sugar and also consult your doctor. Make sure to carry these with you at all times, especially during long travels.

Drug Interactions

Drug-Drug Interaction: Apriglim-M 4 Tablet 10’s may have interaction with antibiotics (rifampicin, trimethoprim), calcium channel blockers (verapamil), antacid (cimetidine), HIV/AIDS drugs (dolutegravir), heart-related medicine (ranolazine), anticancer drugs (vandetanib, crizotinib, olaparib), antifungals (fluconazole, miconazole), water pill (acetazolamide), antidiabetic drug (insulin), anticonvulsants (phenytoin).

Drug- Food Interaction: Apriglim-M 4 Tablet 10’s may interact with alcohol. Therefore, avoid consumption of alcohol with Apriglim-M 4 Tablet 10’s as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Drug-Disease Interaction: If you have severe infections, uncontrolled diabetes, lactic acidosis or ketoacidosis (accumulation of ketone bodies in the blood), dehydration, liver or kidney problems, inform your doctor before taking Apriglim-M 4 Tablet 10’s.