Amazeo OD 400 Tablet (Amisulpride 400mg)

About Amazeo OD 400 Tablet

Amazeo OD 400mg Tablet 10’s belongs to a group of medicines called ‘antipsychotics‘ primarily used to treat long term (chronic) schizophrenia and postoperative nausea/vomiting. Schizophrenia is characterized by hallucinations symptoms (seeing or hearing things that are not real) and delusions (wrong beliefs). In schizophrenic disorders, there are positive symptoms (like delusions, hallucinations and thought disorders) along with negative symptoms (like blunted effect, emotional and social withdrawal). Nausea is an uneasy feeling in which the person feels an urge to vomit, whereas vomiting is an uncontrollable reflex that expels the stomach’s contents through the mouth.

Amazeo OD 400 Tablet 10’s contains Amisulpride, which helps restore the balance of certain natural substances in the brain. The key action of Amazeo OD 400mg Tablet 10’s is to block some of the dopamine receptors in the brain and correct dopamine’s overactivity. On the other hand, it also affects other brain neurotransmitters such as serotonin (5-HT), which may also lead to its beneficial effects. Amazeo OD 400 Tablet 10’s also stops the sensation of vomiting/nausea by blocking the D2 receptors located in the chemoreceptor trigger zone – CTZ of the brain responsible for inducing vomiting.

Take Amazeo OD 400mg Tablet 10’s as prescribed by your doctor. You are advised to take Amazeo OD 400 Tablet 10’s for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience dryness in the mouth, constipation, weight gain, decreased blood pressure, dystonia (involuntary muscle contractions), akathisia (inability to stay still), parkinsonism, increased prolactin level in blood. Most of these side effects of Amazeo OD 400 Tablet 10’s do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Amazeo OD 400 Tablet 10’s or any other medicines, please tell your doctor. Amazeo OD 400 Tablet 10’s is not recommended for children below 18 years of age. If you are pregnant or breastfeeding, please inform your doctor before taking Amazeo OD 400 Tablet 10’s. Use Amazeo OD 400 Tablet 10’s with extreme caution in elderly patients above 65 years of age as there is an increased risk of severe adverse effects.  If you have breast cancer, pheochromocytoma (tumour of the adrenal gland), pituitary gland prolactinoma (tumour of the pituitary gland), fits, Parkinson’s disease, kidney or heart problems, inform your doctor before taking Amazeo OD 400 Tablet 10’s. Drive only if you are alert after taking Amazeo OD 400 Tablet 10’s as it may cause drowsiness or dizziness.

Uses of Amazeo OD 400 Tablet 10’s

Postoperative nausea and vomiting (PONV), Schizophrenia

Medicinal Benefits

Amazeo OD 400 Tablet 10’s contains Amisulpride, a group of medicines called antipsychotics used to treat a mental illness called schizophrenia, dysthymia (long-term depression), and bipolar disorder. Additionally, Amazeo OD 400 Tablet 10’s has anti-emetics properties used either monotherapy or in combination with other antiemetic drugs to prevent nausea and vomiting, which might occur after surgery. The key action of Amazeo OD 400 Tablet 10’s is to block some of the brain’s dopamine receptors and correct dopamine’s overactivity, thereby producing a calming effect in the brain. Altogether, Amazeo OD 400 Tablet 10’s may help decrease hallucinations and help you think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life. Amazeo OD 400 Tablet 10’s is more effective than other antipsychotic drugs such as olanzapine, haloperidol, quetiapine, and clozapine to treat schizophrenic symptoms.

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Directions for Use

Amazeo OD 400 Tablet 10’s is available in tablet, oral solution and injection forms.Tablet: Take Amazeo OD 400 Tablet 10’s as prescribed by your doctor. The doctor determines the dose and duration of the medicine. Swallow the medicines as a whole with a glass of water. Do not crush, chew, or break it. Oral solution: The liquid form of Amazeo OD 400 Tablet 10’s should be taken by mouth using the measuring cup provided by the pack; shake the bottle well before each use.Injection: A healthcare professional will administer the injection form of Amazeo OD 400 Tablet 10’s; do not self-administer. Depending on your medical condition, your doctor will decide how long you need to take Amazeo OD 400 Tablet 10’s.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Amazeo OD 400 Tablet 10’s

• Dizziness
• Drowsiness
• Lightheadedness
• Dry mouth
• Constipation
• Weight gain
• Decreased blood pressure
• Dystonia (involuntary muscle contractions)
• Akathisia (inability to stay still)
• Parkinsonism
• Increased prolactin level in the blood
• Low potassium level

In-Depth Precautions and Warning

Drug Warnings

Do not take Amazeo OD 400 Tablet 10’s if you are allergic (hypersensitive) to olanzapine or any other ingredients present in this medicine or have a medical history of prolactin dependent tumour or breast cancer, phaeochromocytoma (a tumour on the adrenal gland), pituitary tumour. Amazeo OD 400 Tablet 10’s should not be given to children as safety have not been established. Use Amazeo OD 400 Tablet 10’s with extreme caution in elderly patients above 65 years of age as there is an increased risk of severe adverse effects. If you are pregnant or breastfeeding, please consult a doctor before taking Amazeo OD 400 Tablet 10’s. Amazeo OD 400 Tablet 10’s may impair fertility, so inform your doctor if you are planning for pregnancy. Inform your doctor if you are previously diagnosed with kidney disease, liver disease epilepsy or seizures (fits), Parkinson’s disease, unusual heart rate (rhythm), slow heartbeat (less than 55 beats per minute), low potassium levels in your blood, prolonged QT interval (heart conduction problem), if you or someone else in your family has a history of blood clots, heart problems, stroke, diabetes, have a low number of white blood cells (agranulocytosis), leucopenia (blood disorder). Amazeo OD 400 Tablet 10’s may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Amazeo OD 400 Tablet 10’s as it could lead to increased drowsiness and dizziness.

Drug Interactions

Drug-Drug Interaction: Amazeo OD 400 Tablet 10’s may have interaction with medicines used to reduce heart rate (quinidine, disopyramide, amiodarone, sotalol) medicines for high blood pressure and heart problems (diltiazem, verapamil, guanfacine, digitalis, clonidine, bepridil) pain killers (morphine, pethidine, tramadol, indomethacin, aspirin, acetaminophen, hydrocodone) antimalarial (mefloquine), anti-histamines (promethazine, diphenhydramine)  medicine used to treat schizophrenia (clozapine) neuroleptics (pimozide, haloperidol, imipramine, duloxetine, citalopram, sertraline, fluoxetine, paroxetine), anti-anxiety drugs (lorazepam and diazepam), antipsychotics (flupentixol, droperidol, haloperidol, fluphenazine, pipamperone), antibiotics (ciprofloxacin, erythromycin, sparfloxacin, moxifloxacin), antiparkinson (levodopa, ropinirole, bromocriptine).

Drug- Food Interaction: Amazeo OD 400 Tablet 10’s may interact with grapefruit juice and alcohol. Therefore, avoid intake of grapefruit juice and alcohol with Amazeo OD 400 Tablet 10’s as it may increase the risk of adverse effects.

Drug-Disease Interaction: If you have breast cancer, pheochromocytoma (tumour of the adrenal gland), pituitary gland prolactinoma (tumour of the pituitary gland), fits, Parkinson’s disease, kidney or heart problems, inform your doctor before taking Amazeo OD 400 Tablet 10’s.